Payload Information

General Information of This Payload
Payload ID
PAY0NZMYN
Name
Lenalidomide
Synonyms
Lenalidomide
   Click to Show/Hide
Formula
C13H13N3O3
Isosmiles
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
PubChem CID
216326
InChI
InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChIKey
GOTYRUGSSMKFNF-UHFFFAOYSA-N
Pharmaceutical Properties
Molecule Weight
259.265
Polar area
92.5
Complexity
573.701149
xlogp Value
0.0298
Heavy Count
19
Rot Bonds
1
Hbond acc
4
Hbond Donor
2
The activity data of This Payload
Standard Type Value Units Cell line Disease Model Cell line ID Reference
Cellular activity -16 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity -3 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity -4 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity -4.5 %
K562 cells
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive, Chronic myeloid leukemia
CVCL_0004 
Cellular activity -5 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity -6 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity -9 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity -9 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cell-based Percent Inhibition (%) 0.1 %
Vero C1008 cells
Normal
CVCL_0574 
Cell-based Percent Inhibition (%) 0.1 %
Vero C1008 cells
Normal
CVCL_0574 
Cellular activity 10 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 100 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cell-based Percent Inhibition (%) 100 % Undisclosed Undisclosed Undisclosed
Cellular activity 106 %
RAW264.7 cells
Monocytic-macrophage leukemia
CVCL_0493 
Cellular activity 109 %
RAW264.7 cells
Monocytic-macrophage leukemia
CVCL_0493 
Cellular activity 12 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 12 %
G-401 cells
Kidney Wilm's tumor
CVCL_0270 
Cellular activity 13 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cell-based Percent Inhibition (%) 14 %
Jurkat cells
Childhood T acute lymphoblastic leukemia, Precursor T-cell acute lymphoblastic leukemia
CVCL_0065 
Cell-based Percent Inhibition (%) 14 %
Jurkat cells
Childhood T acute lymphoblastic leukemia, Precursor T-cell acute lymphoblastic leukemia
CVCL_0065 
Cellular activity 17.4 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 2 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cell-based Percent Inhibition (%) 20 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Maximum Effect (Emax) 21 %
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
Cell-based Percent Inhibition (%) 25.36 % Undisclosed Undisclosed Undisclosed
Cellular activity 27 % Undisclosed Undisclosed Undisclosed
Cellular activity 29 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 3 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cell-based Percent Inhibition (%) 32 %
HUVEC cells
Normal
CVCL_9S75 
Half Maximal Inhibitory Concentration (IC50) 340.3 ug.mL-1
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 35 % Undisclosed Undisclosed Undisclosed
Cell-based Percent Inhibition (%) 4 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 4 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 46 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cell-based Percent Inhibition (%) <50 %
U-937 cells
Acute monoblastic/monocytic leukemia, Adult acute monocytic leukemia
CVCL_0007 
Cellular activity 57 %
MM1.S cells
Plasma cell myeloma, Multiple myeloma
CVCL_8792 
Cell-based Percent Inhibition (%) 6 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 6 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cell-based Percent Inhibition (%) 62.59 %
MM1.S cells
Plasma cell myeloma, Multiple myeloma
CVCL_8792 
Cell-based Percent Inhibition (%) 64.6 %
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
Cellular activity 65.6 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 7 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 70 %
MM1.S cells
Plasma cell myeloma, Multiple myeloma
CVCL_8792 
Cellular activity 70 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cell-based Percent Inhibition (%) 74 %
PBMC cells
Normal
CVCL_0140 
Maximum Effect (Emax) 75 %
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
Cellular activity 78 %
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Cellular activity 84 % Undisclosed Undisclosed Undisclosed
Cellular activity >85 % Undisclosed Undisclosed Undisclosed
Cellular activity 90 %
MV4-11 cells
Childhood acute monocytic leukemia
CVCL_0064 
Half Maximal Inhibitory Concentration (IC50) 100 nM
PBMC cells
Normal
CVCL_0140 
Half Maximal Inhibitory Concentration (IC50) 100 nM
PBMC cells
Normal
CVCL_0140 
Half Maximal Inhibitory Concentration (IC50) 100 nM
PBMC cells
Normal
CVCL_0140 
Half Maximal Inhibitory Concentration (IC50) 100 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) >10000 nM
K562 cells
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive, Chronic myeloid leukemia
CVCL_0004 
Half Maximal Inhibitory Concentration (IC50) >10000 nM
K562 cells
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive, Chronic myeloid leukemia
CVCL_0004 
Half Maximal Inhibitory Concentration (IC50) >10000 nM
HCC827 cells
Lung adenocarcinoma
CVCL_2063 
Half Maximal Inhibitory Concentration (IC50) >10000 nM
G-401 cells
Kidney Wilm's tumor
CVCL_0270 
Half Maximal Inhibitory Concentration (IC50) >10000 nM
HS-SY-2 cells
Monophasic synovial sarcoma
CVCL_8719 
Half Maximal Effective Concentration (EC50) >10000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) >10000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) >10000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) >10000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) >10000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) >100000 nM
MCF-7 cells
Invasive breast carcinoma of no special type
CVCL_0031 
Half Maximal Inhibitory Concentration (IC50) >100000 nM
MDA-MB-231 cells
Breast adenocarcinoma
CVCL_0062 
Half Maximal Inhibitory Concentration (IC50) >100000 nM
MDA-MB-468 cells
Breast adenocarcinoma
CVCL_0419 
Half Maximal Inhibitory Concentration (IC50) >100000 nM
MX1 cells
Breast carcinoma
CVCL_4774 
Half Maximal Inhibitory Concentration (IC50) 10017.18 nM
HMV-2 cells
Vaginal melanoma
CVCL_1282 
Half Maximal Inhibitory Concentration (IC50) 101947.09 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 1020 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 102128.62 nM
MN-60 cells
Burkitt lymphoma
CVCL_1421 
Half Maximal Inhibitory Concentration (IC50) 103251.63 nM
HL-60 cells
Acute myeloblastic leukemia with maturation, Adult acute myeloid leukemia with maturation
CVCL_0002 
Half Maximal Inhibitory Concentration (IC50) 104250.74 nM
MEL-JUSO cells
Cutaneous melanoma
CVCL_1403 
Half Maximal Inhibitory Concentration (IC50) 106100.1 nM
YH-13 cells
Glioblastoma
CVCL_1795 
Half Maximal Inhibitory Concentration (IC50) 107372.6 nM
HCE-4 cells
Esophageal squamous cell carcinoma
CVCL_1271 
Half Maximal Inhibitory Concentration (IC50) 107439.51 nM
HGC-27 cells
Gastric carcinoma
CVCL_1279 
Half Maximal Inhibitory Concentration (IC50) 107635.12 nM
D-566MG cells
Glioblastoma
CVCL_1166 
Half Maximal Inhibitory Concentration (IC50) 109090.19 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 111274.49 nM
U-266 cells
Plasma cell myeloma
CVCL_0015 
Half Maximal Inhibitory Concentration (IC50) 111419.57 nM
BT-20 cells
Invasive breast carcinoma of no special type
CVCL_0178 
Half Maximal Inhibitory Concentration (IC50) 112308.44 nM
EW-13 cells
Ewing sarcoma
CVCL_1211 
Half Maximal Inhibitory Concentration (IC50) 112601.83 nM
MOLT-16 cells
T acute lymphoblastic leukemia
CVCL_1424 
Half Maximal Inhibitory Concentration (IC50) 114380.77 nM
SJRH30 cells
Alveolar rhabdomyosarcoma
CVCL_0041 
Half Maximal Inhibitory Concentration (IC50) 11446.73 nM
HCC1806 cells
Breast acantholytic squamous cell carcinoma
CVCL_1258 
Half Maximal Inhibitory Concentration (IC50) 115672.97 nM
LoVo cells
Colon adenocarcinoma
CVCL_0399 
Half Maximal Inhibitory Concentration (IC50) 11571.04 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 115727 nM
G-361 cells
Melanoma
CVCL_1220 
Half Maximal Inhibitory Concentration (IC50) 116343.38 nM
LOX IMVI cells
Melanoma
CVCL_1381 
Half Maximal Inhibitory Concentration (IC50) 117727.31 nM
LS-123 cells
Colon adenocarcinoma
CVCL_1383 
Half Maximal Inhibitory Concentration (IC50) 118120.35 nM
NCI-H1792 cells
Lung adenocarcinoma
CVCL_1495 
Half Maximal Inhibitory Concentration (IC50) 118224.34 nM
OVCAR-8 cells
High grade ovarian serous adenocarcinoma
CVCL_1629 
Half Maximal Inhibitory Concentration (IC50) 118278.74 nM
HH cells
T-cell non-Hodgkin lymphoma
CVCL_1280 
Half Maximal Inhibitory Concentration (IC50) 118559.15 nM
PSN1 cells
Pancreatic adenocarcinoma
CVCL_1644 
Half Maximal Inhibitory Concentration (IC50) 119266.32 nM
HCT-15 cells
Colon adenocarcinoma
CVCL_0292 
Half Maximal Inhibitory Concentration (IC50) 119403.56 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 11976.42 nM
SK-MEL-28 cells
Cutaneous melanoma
CVCL_0526 
Half Maximal Inhibitory Concentration (IC50) 119790.33 nM
HPAF-II cells
Pancreatic ductal adenocarcinoma
CVCL_0313 
Half Maximal Degradation Concentration (DC50) 120 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
Half Maximal Inhibitory Concentration (IC50) 1200 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 120479.19 nM
J-RT3-T3-5 cells
T acute lymphoblastic leukemi
CVCL_1316 
Half Maximal Inhibitory Concentration (IC50) 121107.91 nM
C32 cells
Amelanotic melanoma
CVCL_1097 
Half Maximal Inhibitory Concentration (IC50) 121845.52 nM
NCI-H1437 cells
Lung adenocarcinoma
CVCL_1472 
Half Maximal Inhibitory Concentration (IC50) 122668.43 nM
KGN cells
Ovarian granulosa cell tumor
CVCL_0375 
Half Maximal Inhibitory Concentration (IC50) 122847.41 nM
NCI-H2029 cells
Lung small cell carcinoma
CVCL_1516 
Half Maximal Inhibitory Concentration (IC50) 122884.64 nM
SCC-4 cells
Tongue squamous cell carcinoma
CVCL_1684 
Half Maximal Inhibitory Concentration (IC50) 124633.45 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Activity Concentration (AC50) 1258.9 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 12624.14 nM
RPMI-8226 cells
Plasma cell myeloma
CVCL_0014 
Half Maximal Inhibitory Concentration (IC50) 128046.44 nM
IST-MES1 cells
Pleural epithelioid mesothelioma
CVCL_1311 
Half Maximal Inhibitory Concentration (IC50) 128072.56 nM
A4-Fuk cells
B acute lymphoblastic leukemia
CVCL_1064 
Half Maximal Inhibitory Concentration (IC50) 128333.97 nM
SW1463 cells
Rectal adenocarcinoma
CVCL_1718 
Half Maximal Inhibitory Concentration (IC50) 129046.4 nM
NUGC-3 cells
Gastric adenocarcinoma
CVCL_1612 
Half Maximal Inhibitory Concentration (IC50) 129069.88 nM
HLE cells
Hepatocellular carcinoma
CVCL_1281 
Half Maximal Inhibitory Concentration (IC50) 129661.86 nM
JVM-2 cells
Mantle cell lymphoma
CVCL_1319 
Half Maximal Inhibitory Concentration (IC50) 129955.23 nM
BPH-1 cells
Benign prostatic hyperplasia
CVCL_1091 
Half Maximal Inhibitory Concentration (IC50) 130253.95 nM
NCI-H1770 cells
Lung non-small cell carcinoma
CVCL_1493 
Half Maximal Inhibitory Concentration (IC50) 130772.61 nM
T24 cells
Bladder carcinoma
CVCL_0554 
Half Maximal Inhibitory Concentration (IC50) 130857.11 nM
SW948 cells
Colon adenocarcinoma
CVCL_0632 
Half Maximal Inhibitory Concentration (IC50) 131616.71 nM
JVM-3 cells
B-cell prolymphocytic leukemia
CVCL_1320 
Half Maximal Inhibitory Concentration (IC50) 13209.85 nM
T47D cells
Invasive breast carcinoma of no special type
CVCL_0553 
Half Maximal Inhibitory Concentration (IC50) 132762.66 nM
ALL-PO cells
B acute lymphoblastic leukemia
CVCL_1069 
Half Maximal Inhibitory Concentration (IC50) >133000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) >133000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) >133000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) >133000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 133176.86 nM
HOS cells
Osteosarcoma
CVCL_0312 
Half Maximal Inhibitory Concentration (IC50) 133483.52 nM
DJM-1 cells
Skin squamous cell carcinoma
CVCL_1172 
Half Maximal Inhibitory Concentration (IC50) 133875.6 nM
DOHH2 cells
Diffuse large B-cell lymphoma germinal center B-cell type
CVCL_1179 
Half Maximal Inhibitory Concentration (IC50) 134100.03 nM
SK-MEL-1 cells
Metastatic melanoma
CVCL_0068 
Half Maximal Inhibitory Concentration (IC50) 134368.9 nM
EGI-1 cells
Cholangiocarcinoma
CVCL_1193 
Half Maximal Inhibitory Concentration (IC50) 134433.68 nM
NCI-H1092 cells
Lung small cell carcinoma
CVCL_1454 
Half Maximal Inhibitory Concentration (IC50) 134518.27 nM
DU-4475 cells
Breast adenocarcinoma
CVCL_1183 
Half Maximal Inhibitory Concentration (IC50) 13479.97 nM
HOP-62 cells
Non-small cell lung carcinoma
CVCL_1285 
Half Maximal Inhibitory Concentration (IC50) 135588.69 nM
UACC-893 cells
Breast carcinoma
CVCL_1782 
Half Maximal Inhibitory Concentration (IC50) 136133.5 nM
TE-11 cells
Esophageal squamous cell carcinoma
CVCL_1761 
Half Maximal Inhibitory Concentration (IC50) 136816.42 nM
DBTRG-05MG cells
Anaplastic astrocytoma
CVCL_1169 
Half Maximal Inhibitory Concentration (IC50) 13819.86 nM
A2058 cells
Melanoma
CVCL_1059 
Half Maximal Inhibitory Concentration (IC50) 138281.71 nM
HCC1937 cells
Breast ductal carcinoma
CVCL_0290 
Half Maximal Inhibitory Concentration (IC50) 138377.58 nM
MKN-45 cells
Gastric adenocarcinoma
CVCL_0434 
Half Maximal Inhibitory Concentration (IC50) 139141.72 nM
SW982 cells
Biphasic synovial sarcoma
CVCL_1734 
Half Maximal Inhibitory Concentration (IC50) 139235.12 nM
TK-10 cells
Renal carcinoma
CVCL_1773 
Half Maximal Inhibitory Concentration (IC50) 140073.6 nM
SW837 cells
Rectal adenocarcinoma
CVCL_1729 
Half Maximal Inhibitory Concentration (IC50) 140755.03 nM
KALS-1 cells
Glioblastoma
CVCL_1323 
Half Maximal Inhibitory Concentration (IC50) 141693.46 nM
SN12C cells
Renal cell carcinoma
CVCL_1705 
Half Maximal Inhibitory Concentration (IC50) 142248.42 nM
Lu-65 cells
Lung giant cell carcinoma
CVCL_1392 
Half Maximal Inhibitory Concentration (IC50) 14247.27 nM
SW620 cells
Colon adenocarcinoma
CVCL_0547 
Half Maximal Inhibitory Concentration (IC50) 143137.83 nM
D-502MG cells
Glioblastoma
CVCL_1162 
Half Maximal Inhibitory Concentration (IC50) 143704.63 nM
A673 cells
Rhabdomyosarcoma
CVCL_0080 
Half Maximal Inhibitory Concentration (IC50) 14489.24 nM
LCLC-103H cells
Lung large cell carcinoma
CVCL_1375 
Half Maximal Inhibitory Concentration (IC50) 144941.76 nM
GB-1 cells
Glioblastoma
CVCL_1227 
Half Maximal Inhibitory Concentration (IC50) 14579.58 nM
HAL-01 cells
B acute lymphoblastic leukemia
CVCL_1242 
Half Maximal Inhibitory Concentration (IC50) 146111.2 nM
COLO-668 cells
Lung small cell carcinoma
CVCL_1128 
Half Maximal Inhibitory Concentration (IC50) 146291.18 nM
OS-RC-2 cells
Clear cell renal cell carcinoma
CVCL_1626 
Half Maximal Inhibitory Concentration (IC50) 148384.96 nM
HCC 2998 cells
Colon adenocarcinoma
CVCL_1266 
Half Maximal Inhibitory Concentration (IC50) 148555.11 nM
IST-MEL1 cells
Melanoma
CVCL_1308 
Half Maximal Inhibitory Concentration (IC50) 148866.21 nM
KYSE-180 cells
Esophageal squamous cell carcinoma
CVCL_1349 
Half Maximal Inhibitory Concentration (IC50) 148879.76 nM
SF-295 cells
Glioblastoma
CVCL_1690 
Half Maximal Inhibitory Concentration (IC50) 14910.85 nM
PANC-08-13 cells
Pancreatic ductal adenocarcinoma
CVCL_1638 
Half Maximal Inhibitory Concentration (IC50) 149917.63 nM
KYSE-70 cells
Esophageal squamous cell carcinoma
CVCL_1356 
Half Maximal Effective Concentration (EC50) 150 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 1500 nM
Sf9 cells
Normal
CVCL_0549 
Half Maximal Inhibitory Concentration (IC50) 150338.89 nM
BT-474 cells
Invasive breast carcinoma of no special type
CVCL_0179 
Half Maximal Inhibitory Concentration (IC50) 152053.74 nM
KARPAS-299 cells
ALK-positive anaplastic large cell lymphoma
CVCL_1324 
Half Maximal Inhibitory Concentration (IC50) 15397.88 nM
COLO-684 cells
Endometrial adenocarcinoma
CVCL_1132 
Half Maximal Inhibitory Concentration (IC50) 15498.99 nM
DEL cells
Anaplastic large cell lymphoma
CVCL_1170 
Half Maximal Inhibitory Concentration (IC50) 155545.77 nM
HT cells
Diffuse large B-cell lymphoma
CVCL_1290 
Half Maximal Inhibitory Concentration (IC50) 155951.96 nM
KS-1 cells
Glioblastoma
CVCL_1343 
Half Maximal Inhibitory Concentration (IC50) 156330.6 nM
MEG-01 cells
Chronic myeloid leukemia
CVCL_0425 
Half Maximal Inhibitory Concentration (IC50) 156560.89 nM
ME-180 cells
Cervical squamous cell carcinoma
CVCL_1401 
Half Maximal Inhibitory Concentration (IC50) 156694.96 nM
ES8 cells
Ewing sarcoma
CVCL_1204 
Half Maximal Inhibitory Concentration (IC50) 157115.78 nM
GP5d cells
Colon adenocarcinoma
CVCL_1235 
Half Maximal Inhibitory Concentration (IC50) 157203.48 nM
TCCSUP cells
Bladder carcinoma
CVCL_1738 
Half Maximal Inhibitory Concentration (IC50) 159654.64 nM
CCRF-CEM cells
T acute lymphoblastic leukemia
CVCL_0207 
Half Maximal Inhibitory Concentration (IC50) 159747.91 nM
MDA-MB-231 cells
Breast adenocarcinoma
CVCL_0062 
Half Maximal Inhibitory Concentration (IC50) 161409.4 nM
GAMG cells
Glioblastoma
CVCL_1226 
Half Maximal Inhibitory Concentration (IC50) 16148.61 nM
K5 cells
Thyroid gland papillary carcinoma
CVCL_1322 
Half Maximal Inhibitory Concentration (IC50) 161954.43 nM
MS-1 cells
Lung small cell carcinoma
CVCL_IQ55 
Half Maximal Inhibitory Concentration (IC50) 161961.56 nM
ETK-1 cells
Cholangiocarcinoma
CVCL_1206 
Half Maximal Inhibitory Concentration (IC50) 162005.45 nM
J82 cells
Bladder carcinoma
CVCL_0359 
Half Maximal Inhibitory Concentration (IC50) 162067.03 nM
D-392MG cells
Glioblastoma
CVCL_1158 
Half Maximal Inhibitory Concentration (IC50) 163407.16 nM
Ca-Ski cells
Cervical squamous cell carcinoma
CVCL_1100 
Half Maximal Inhibitory Concentration (IC50) 163414.02 nM
PA-1 cells
Ovarian mixed germ cell tumor
CVCL_0479 
Half Maximal Inhibitory Concentration (IC50) 163540.06 nM
HuO-3N1 cells
Osteosarcoma
CVCL_1297 
Half Maximal Inhibitory Concentration (IC50) 16465.2 nM
SK-MEL-24 cells
Melanoma
CVCL_0599 
Half Maximal Inhibitory Concentration (IC50) 164790.83 nM
NCI-H630 cells
Colon carcinoma
CVCL_1572 
Half Maximal Inhibitory Concentration (IC50) 16529.74 nM
ACN cells
Melanoma
CVCL_1068 
Half Maximal Inhibitory Concentration (IC50) 165668.53 nM
RMG-I cells
Ovarian clear cell adenocarcinoma
CVCL_1662 
Half Maximal Inhibitory Concentration (IC50) 16626.02 nM
H9 cells
Sezary syndrome
CVCL_1240 
Half Maximal Inhibitory Concentration (IC50) 166745.55 nM
DB cells
Diffuse large B-cell lymphoma
CVCL_1168 
Half Maximal Inhibitory Concentration (IC50) 167227.14 nM
OVCAR-3 cells
High grade ovarian serous adenocarcinoma
CVCL_0465 
Half Maximal Inhibitory Concentration (IC50) 167989.59 nM
NCI-H2405 cells
Pleural mesothelioma
CVCL_1551 
Half Maximal Inhibitory Concentration (IC50) 170037.67 nM
A-427 cells
Lung carcinoma
CVCL_1055 
Half Maximal Inhibitory Concentration (IC50) 170191.11 nM
KINGS-1 cells
Anaplastic astrocytoma
CVCL_1328 
Half Maximal Inhibitory Concentration (IC50) 170818.91 nM
NCI-H1299 cells
Lung large cell carcinoma
CVCL_0060 
Half Maximal Inhibitory Concentration (IC50) 17142.95 nM
EM-2 cells
Chronic myeloid leukemia
CVCL_1196 
Half Maximal Inhibitory Concentration (IC50) 174089.41 nM
BB30-HNC cells
Head and neck squamous cell carcinoma
CVCL_1076 
Half Maximal Inhibitory Concentration (IC50) 174322.32 nM
NMC-G1 cells
Astrocytoma
CVCL_1608 
Half Maximal Inhibitory Concentration (IC50) 175667.32 nM
AGS cells
Gastric adenocarcinoma
CVCL_0139 
Half Maximal Inhibitory Concentration (IC50) 176122.72 nM
ES4 cells
Ewing sarcoma
CVCL_1200 
Half Maximal Inhibitory Concentration (IC50) 176125.36 nM
SK-LU-1 cells
Lung adenocarcinoma
CVCL_0629 
Half Maximal Inhibitory Concentration (IC50) 17660.14 nM
HSC-4 cells
Cervical lymph node
CVCL_1289 
Half Maximal Inhibitory Concentration (IC50) 177340.21 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 17782.97 nM
IGROV-1 cells
Endometrioid carcinoma of ovary, Ovarian endometrioid adenocarcinoma
CVCL_1304 
Half Maximal Inhibitory Concentration (IC50) 177822.7 nM
NCI-H2122 cells
Lung adenocarcinoma
CVCL_1531 
Half Maximal Activity Concentration (AC50) 1780 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 178649.72 nM
L-428 cells
Hodgkin lymphoma
CVCL_1361 
Half Maximal Inhibitory Concentration (IC50) 179802.5 nM
ZR-75-30 cells
Breast carcinoma
CVCL_1661 
Half Maximal Inhibitory Concentration (IC50) 17996.8 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 181857.97 nM
NCI-H1573 cells
Lung adenocarcinoma
CVCL_1478 
Half Maximal Inhibitory Concentration (IC50) 184283.99 nM
COR-L88 cells
Lung small cell carcinoma
CVCL_1141 
Half Maximal Inhibitory Concentration (IC50) 187813.23 nM
HCC1187 cells
Breast ductal carcinoma
CVCL_1247 
Half Maximal Inhibitory Concentration (IC50) 188296.91 nM
NB14 cells
Neuroblastoma
CVCL_1444 
Half Maximal Inhibitory Concentration (IC50) 189252.48 nM
RXF 393 cells
Renal carcinoma
CVCL_1673 
Half Maximal Inhibitory Concentration (IC50) 189591.93 nM
KG-1 cells
Adult acute myeloid leukemia
CVCL_0374 
Half Maximal Inhibitory Concentration (IC50) 190 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 19000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 190981.39 nM
SK-MEL-30 cells
Cutaneous melanoma
CVCL_0039 
Half Maximal Inhibitory Concentration (IC50) 191085.89 nM
BB65-RCC cells
Renal cell carcinoma
CVCL_1078 
Half Maximal Inhibitory Concentration (IC50) 192558.31 nM
HC-1 cells
Hairy cell leukemia
CVCL_1243 
Half Maximal Inhibitory Concentration (IC50) 193570.15 nM
SK-UT-1 cells
Uterine corpus leiomyosarcoma
CVCL_0533 
Half Maximal Inhibitory Concentration (IC50) 193628.62 nM
CAL-54 cells
Renal cell carcinoma
CVCL_1111 
Half Maximal Inhibitory Concentration (IC50) 195322.49 nM
LB373-MEL-D cells
Melanoma
CVCL_1367 
Half Maximal Inhibitory Concentration (IC50) 195581.27 nM
LC-2-ad cells
Lung adenocarcinoma
CVCL_1373 
Half Maximal Inhibitory Concentration (IC50) 195781.65 nM
ESS-1 cells
Endometrioid stromal sarcoma
CVCL_1205 
Half Maximal Inhibitory Concentration (IC50) 196712.25 nM
LU-134-A cells
Lung small cell carcinoma
CVCL_1387 
Half Maximal Inhibitory Concentration (IC50) 197112.57 nM
NOMO-1 cells
Acute monocytic leukemia
CVCL_1609 
Half Maximal Inhibitory Concentration (IC50) 197649.45 nM
C2BBe1 cells
Colon adenocarcinoma
CVCL_1096 
Half Maximal Inhibitory Concentration (IC50) 197776.18 nM
MZ7-mel cells
Melanoma
CVCL_1436 
Half Maximal Inhibitory Concentration (IC50) 19907.59 nM
LN-405 cells
Glioblastoma
CVCL_1378 
Half Maximal Inhibitory Concentration (IC50) >19952.62 nM
Vero C1008 cells
Normal
CVCL_0574 
Half Maximal Inhibitory Concentration (IC50) 199740.89 nM
NCI-H82 cells
Lung small cell carcinoma
CVCL_1591 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
PBMC cells
Normal
CVCL_0140 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
JeKo-1 cells
Mantle cell lymphoma
CVCL_1865 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
JeKo-1 cells
Mantle cell lymphoma
CVCL_1865 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
JeKo-1 cells
Mantle cell lymphoma
CVCL_1865 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
MM1.S cells
Plasma cell myeloma, Multiple myeloma
CVCL_8792 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
Raji cells
EBV-related Burkitt lymphoma
CVCL_0511 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
THP-1 cells
Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia
CVCL_0006 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
RPMI-8226 cells
Plasma cell myeloma
CVCL_0014 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
MV4-11 cells
Childhood acute monocytic leukemia
CVCL_0064 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
MV4-11 cells
Childhood acute monocytic leukemia
CVCL_0064 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
MINO cells
Mantle cell lymphoma
CVCL_1872 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
U-266 cells
Plasma cell myeloma
CVCL_0015 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) >20000 nM
Vero C1008 cells
Normal
CVCL_0574 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
WI-38 cells
Normal
CVCL_0579 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
MCF-10A cells
Normal
CVCL_0598 
Half Maximal Inhibitory Concentration (IC50) >20000 nM
Z-138 cells
Mantle cell lymphoma
CVCL_B077 
Half Maximal Inhibitory Concentration (IC50) >20000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 200734.47 nM
NCI-H2228 cells
Lung adenocarcinoma
CVCL_1543 
Half Maximal Inhibitory Concentration (IC50) 20357.31 nM
MSTO-211H cells
Pleural biphasic mesothelioma
CVCL_1430 
Half Maximal Inhibitory Concentration (IC50) 203805.07 nM
KE-37 cells
T acute lymphoblastic leukemia
CVCL_1327 
Half Maximal Inhibitory Concentration (IC50) 204168.78 nM
HT-144 cells
Melanoma
CVCL_0318 
Half Maximal Inhibitory Concentration (IC50) 204278.45 nM
769-P cells
Renal cell carcinom
CVCL_1050 
Half Maximal Inhibitory Concentration (IC50) 20575.87 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
Half Maximal Inhibitory Concentration (IC50) 205847.99 nM
HCC1954 cells
Breast ductal carcinoma
CVCL_1259 
Half Maximal Inhibitory Concentration (IC50) 206803.9 nM
NCI-H1838 cells
Lung adenocarcinoma
CVCL_1499 
Half Maximal Inhibitory Concentration (IC50) 206829.96 nM
RKO cells
Colon carcinoma
CVCL_0504 
Half Maximal Inhibitory Concentration (IC50) 207738.9 nM
IST-SL1 cells
Lung small cell carcinoma
CVCL_1313 
Half Maximal Inhibitory Concentration (IC50) 208176.44 nM
HT-29 cells
Colon adenocarcinoma
CVCL_0320 
Half Maximal Inhibitory Concentration (IC50) 209297.57 nM
RPMI-7951 cells
Malignant melanoma
CVCL_1666 
Half Maximal Inhibitory Concentration (IC50) 210060.59 nM
KM12 cells
Colon adenocarcinoma
CVCL_1331 
Half Maximal Inhibitory Concentration (IC50) 210850.22 nM
CAL-27 cells
Tongue adenosquamous carcinom
CVCL_1107 
Half Maximal Inhibitory Concentration (IC50) 211318.82 nM
Panc1005 cells
Pancreatic ductal adenocarcinoma
CVCL_1639 
Half Maximal Inhibitory Concentration (IC50) 211670.75 nM
NB7 cells
Neuroblastoma
CVCL_8824 
Half Maximal Inhibitory Concentration (IC50) 212078.82 nM
CFPAC-1 cells
Cystic fibrosis, Pancreatic ductal adenocarcinoma
CVCL_1119 
Half Maximal Inhibitory Concentration (IC50) 213727.32 nM
NB13 cells
Neuroblastoma
CVCL_1443 
Half Maximal Inhibitory Concentration (IC50) 214315.45 nM
HuO9 cells
Osteosarcoma
CVCL_1298 
Half Maximal Inhibitory Concentration (IC50) 2150.38 nM
LB771-HNC cells
Head and neck squamous cell carcinoma
CVCL_1369 
Half Maximal Inhibitory Concentration (IC50) 215906.84 nM
SW756 cells
Cervical squamous cell carcinoma
CVCL_1727 
Half Maximal Inhibitory Concentration (IC50) 216248.45 nM
SCC-15 cells
Squamous cell carcinoma of the oral tongue, Tongue squamous cell carcinoma
CVCL_1681 
Half Maximal Inhibitory Concentration (IC50) 216887.55 nM
D-263MG cells
Glioblastoma
CVCL_1154 
Half Maximal Inhibitory Concentration (IC50) 217280.69 nM
CaR-1 cells
Rectal adenocarcinoma
CVCL_1116 
Half Maximal Inhibitory Concentration (IC50) 219234.08 nM
AM-38 cells
Glioblastoma
CVCL_1070 
Half Maximal Inhibitory Concentration (IC50) 220 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 22156.28 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 221861.87 nM
TGBC1TKB cells
Gallbladder undifferentiated carcinoma
CVCL_1769 
Half Maximal Inhibitory Concentration (IC50) 222621.94 nM
A204 cells
Rhabdomyosarcoma
CVCL_1058 
Half Maximal Inhibitory Concentration (IC50) 223164.46 nM
HSC-3 cells
Oral squamous cell carcinoma
CVCL_1288 
Half Maximal Inhibitory Concentration (IC50) 223169.37 nM
RT-112 cells
Bladder carcinoma
CVCL_1670 
Half Maximal Inhibitory Concentration (IC50) 223943.77 nM
NCI-H810 cells
Lung large cell carcinoma
CVCL_1590 
Half Maximal Inhibitory Concentration (IC50) 224073.92 nM
ASPC1 cells
Pancreatic ductal adenocarcinoma
CVCL_0152 
Half Maximal Inhibitory Concentration (IC50) 224448.44 nM
NCI-H1563 cells
Lung adenocarcinoma
CVCL_1475 
Half Maximal Inhibitory Concentration (IC50) 225417.45 nM
HD-MY-Z cells
Acute myeloid leukemia
CVCL_1273 
Half Maximal Inhibitory Concentration (IC50) 22696.3 nM
ES3 cells
Ewing sarcoma
CVCL_1199 
Half Maximal Inhibitory Concentration (IC50) 227213.02 nM
UMC-11 cells
Lung carcinoid tumor
CVCL_1784 
Half Maximal Inhibitory Concentration (IC50) 227792.02 nM
IA-LM cells
Lung large cell carcinoma
CVCL_1302 
Half Maximal Inhibitory Concentration (IC50) 228260.61 nM
647-V cells
Bladder carcinoma
CVCL_1049 
Half Maximal Inhibitory Concentration (IC50) 228942.3 nM
SK-N-DZ cells
Neuroblastoma
CVCL_1701 
Half Maximal Inhibitory Concentration (IC50) 229966.81 nM
TGBC24TKB cells
Gallbladder carcinoma
CVCL_1770 
Half Maximal Inhibitory Concentration (IC50) 230215.54 nM
SK-MEL-2 cells
Melanoma
CVCL_0069 
Half Maximal Inhibitory Concentration (IC50) 232230.17 nM
786-O cells
Renal cell carcinoma
CVCL_1051 
Half Maximal Inhibitory Concentration (IC50) 234106.47 nM
BALL-1 cells
B acute lymphoblastic leukemia
CVCL_1075 
Half Maximal Inhibitory Concentration (IC50) 235430.09 nM
639-V cells
Ureter urothelial carcinoma
CVCL_1048 
Half Maximal Inhibitory Concentration (IC50) 235887.5 nM
RD cells
Rhabdomyosarcoma
CVCL_1649 
Half Maximal Inhibitory Concentration (IC50) 236759.3 nM
MIA PaCa-2 cells
Pancreatic undifferentiated carcinoma
CVCL_0428 
Half Maximal Inhibitory Concentration (IC50) 238657.39 nM
NCI-H1975 cells
Lung adenocarcinoma
CVCL_1511 
Half Maximal Inhibitory Concentration (IC50) 23869.61 nM
SBC-1 cells
Lung small cell carcinoma
CVCL_1676 
Half Maximal Inhibitory Concentration (IC50) 242480.91 nM
NCI-H2009 cells
Lung adenocarcinoma
CVCL_1514 
Half Maximal Inhibitory Concentration (IC50) 242487.95 nM
CHL-1 cells
Melanoma
CVCL_1122 
Half Maximal Inhibitory Concentration (IC50) 243601.09 nM
SAS cells
Tongue squamous cell carcinoma
CVCL_1675 
Half Maximal Inhibitory Concentration (IC50) 246271.36 nM
CAPAN-1 cells
Pancreatic ductal adenocarcinoma
CVCL_0237 
Half Maximal Inhibitory Concentration (IC50) 246720.22 nM
NB17 cells
Neuroblastoma
CVCL_1445 
Half Maximal Inhibitory Concentration (IC50) 25014.88 nM
CTV-1 cells
T acute lymphoblastic leukemia
CVCL_1150 
Half Maximal Inhibitory Concentration (IC50) 253712.31 nM
KOSC-2 cells
Floor of mouth squamous cell carcinoma
CVCL_1337 
Half Maximal Inhibitory Concentration (IC50) 25400.91 nM
HuP-T3 cells
Pancreatic adenocarcinoma
CVCL_1299 
Half Maximal Inhibitory Concentration (IC50) 255143.72 nM
NY cells
Osteosarcoma
CVCL_1613 
Half Maximal Inhibitory Concentration (IC50) 25540.72 nM
HCC2218 cells
Breast ductal carcinoma
CVCL_1263 
Half Maximal Inhibitory Concentration (IC50) 257142.65 nM
BFTC-905 cells
Bladder carcinoma
CVCL_1083 
Half Maximal Inhibitory Concentration (IC50) 257212.35 nM
HTC-C3 cells
Thyroid gland anaplastic carcinoma
CVCL_1295 
Half Maximal Inhibitory Concentration (IC50) 257975.34 nM
GOTO cells
Adrenal gland neuroblastoma
CVCL_1234 
Half Maximal Inhibitory Concentration (IC50) 258275.28 nM
NCI-H661 cells
Lung large cell carcinoma
CVCL_1577 
Half Maximal Inhibitory Concentration (IC50) 263114.95 nM
HO-1-N-1 cells
Buccal mucosa squamous cell carcinoma
CVCL_1284 
Half Maximal Inhibitory Concentration (IC50) 263588.98 nM
Ca9-22 cells
Gingival squamous cell carcinoma
CVCL_1102 
Half Maximal Inhibitory Concentration (IC50) 264426.68 nM
ACHN cells
Renal adenocarcinoma
CVCL_1067 
Half Maximal Inhibitory Concentration (IC50) 267747.13 nM
SW1088 cells
Astrocytoma
CVCL_1715 
Half Maximal Inhibitory Concentration (IC50) 268516.94 nM
HEC-1 cells
Endometrial adenocarcinoma
CVCL_1274 
Half Maximal Inhibitory Concentration (IC50) 270077.24 nM
PC-14 cells
Lung adenocarcinoma
CVCL_1640 
Half Maximal Inhibitory Concentration (IC50) 270820.98 nM
BEN cells
Lung non-small cell carcinoma
CVCL_1082 
Half Maximal Inhibitory Concentration (IC50) 271591.74 nM
BE-13 cells
T acute lymphoblastic leukemia
CVCL_1081 
Half Maximal Inhibitory Concentration (IC50) 271628.14 nM
BHY cells
Head and neck squamous cell carcinoma
CVCL_1086 
Half Maximal Inhibitory Concentration (IC50) 272072.62 nM
FaDu cells
Hypopharyngeal squamous cell carcinoma
CVCL_1218 
Half Maximal Inhibitory Concentration (IC50) 272347.28 nM
U2OS cells
Osteosarcoma
CVCL_0042 
Half Maximal Inhibitory Concentration (IC50) 273289.32 nM
COLO-792 cells
Melanoma
CVCL_1134 
Half Maximal Inhibitory Concentration (IC50) 273599.13 nM
VM-CUB-1 cells
Bladder carcinoma
CVCL_1786 
Half Maximal Inhibitory Concentration (IC50) 275242.08 nM
A101D cells
Melanoma
CVCL_1057 
Half Maximal Inhibitory Concentration (IC50) 276338.62 nM
NB10 cells
Neuroblastoma
CVCL_1441 
Half Maximal Inhibitory Concentration (IC50) 276374.82 nM
NCI-H1650 cells
Lung adenocarcinoma
CVCL_1483 
Half Maximal Inhibitory Concentration (IC50) 277036.98 nM
EFO-27 cells
Ovarian mucinous adenocarcinoma
CVCL_1192 
Half Maximal Inhibitory Concentration (IC50) 277515.56 nM
D-542MG cells
Glioblastoma
CVCL_1164 
Half Maximal Inhibitory Concentration (IC50) 278344.62 nM
HN cells
Cervical lymph node
CVCL_1283 
Half Maximal Inhibitory Concentration (IC50) 280389.86 nM
NCI-H2030 cells
Lung adenocarcinoma
CVCL_1517 
Half Maximal Inhibitory Concentration (IC50) 280913.56 nM
HCT116 cells
Colon carcinoma
CVCL_0291 
Half Maximal Inhibitory Concentration (IC50) 281707.98 nM
SW 954 cells
Vulva squamous carcinoma
CVCL_1732 
Half Maximal Inhibitory Concentration (IC50) 282007.59 nM
RCC10RGB cells
Renal cell carcinoma
CVCL_1647 
Half Maximal Inhibitory Concentration (IC50) 28202.62 nM
HDLM-2 cells
Hodgkin lymphoma
CVCL_0009 
Half Maximal Inhibitory Concentration (IC50) 282313.17 nM
HUTU 80 cells
Duodenal adenocarcinoma
CVCL_1301 
Half Maximal Inhibitory Concentration (IC50) 283199.05 nM
NCI-H1355 cells
Lung adenocarcinoma
CVCL_1464 
Half Maximal Inhibitory Concentration (IC50) 284668.12 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 284719.93 nM
KYSE-410 cells
Esophageal squamous cell carcinoma
CVCL_1352 
Half Maximal Inhibitory Concentration (IC50) 285561.67 nM
KP-4 cells
Pancreatic carcinoma
CVCL_1338 
Half Maximal Inhibitory Concentration (IC50) 286 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 290168.56 nM
HOP-92 cells
Non-small cell lung carcinoma
CVCL_1286 
Half Maximal Inhibitory Concentration (IC50) 291152.74 nM
ES5 cells
Ewing sarcoma
CVCL_1201 
Half Maximal Inhibitory Concentration (IC50) 291804.78 nM
VA-ES-BJ cells
Epithelioid sarcoma
CVCL_1785 
Half Maximal Inhibitory Concentration (IC50) 2922.12 nM
L-363 cells
Plasma cell myeloma
CVCL_1357 
Half Maximal Inhibitory Concentration (IC50) 292334.3 nM
NCI-H28 cells
Pleural mesothelioma
CVCL_1555 
Half Maximal Inhibitory Concentration (IC50) 294134.75 nM
SW13 cells
Adrenal cortex carcinoma
CVCL_0542 
Half Maximal Inhibitory Concentration (IC50) 294226.24 nM
KYSE-450 cells
Esophageal squamous cell carcinoma
CVCL_1353 
Half Maximal Inhibitory Concentration (IC50) 294578.05 nM
NCI-H2170 cells
Lung squamous cell carcinoma
CVCL_1535 
Half Maximal Inhibitory Concentration (IC50) 294681.17 nM
RPMI-8866 cells
Chronic myelogenous leukemia
CVCL_1668 
Half Maximal Inhibitory Concentration (IC50) 295338.75 nM
GCIY cells
Gastric adenocarcinoma
CVCL_1228 
Half Maximal Inhibitory Concentration (IC50) 295593.74 nM
NCI-H226 cells
Pleural epithelioid mesothelioma
CVCL_1544 
Half Maximal Inhibitory Concentration (IC50) 296519.8 nM
NCI-H1793 cells
Lung adenocarcinoma
CVCL_1496 
Half Maximal Inhibitory Concentration (IC50) 29697.41 nM
ABC-1 cells
Lung adenocarcinoma
CVCL_1066 
Half Maximal Inhibitory Concentration (IC50) 2970.01 nM
JAR cells
Gestational choriocarcinoma
CVCL_0360 
Half Maximal Inhibitory Concentration (IC50) 29731.74 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 297739.52 nM
MFE-280 cells
Endometrial adenocarcinoma
CVCL_1405 
Half Maximal Inhibitory Concentration (IC50) 299444.77 nM
BFTC-909 cells
Renal pelvis urothelial carcinoma
CVCL_1084 
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >30000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) >300000 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 301038.75 nM
NCI-H292 cells
Lung mucoepidermoid carcinoma
CVCL_0455 
Half Maximal Inhibitory Concentration (IC50) 301583.82 nM
NCI-H1703 cells
Lung squamous cell carcinoma
CVCL_1490 
Half Maximal Inhibitory Concentration (IC50) 301842.69 nM
NCI-H1155 cells
Lung large cell carcinoma
CVCL_1456 
Half Maximal Inhibitory Concentration (IC50) 30309.86 nM
WM-115 cells
Melanoma
CVCL_0040 
Half Maximal Inhibitory Concentration (IC50) 303266.21 nM
Calu-6 cells
Lung adenocarcinoma
CVCL_0236 
Half Maximal Inhibitory Concentration (IC50) 30330.05 nM
SW1990 cells
Pancreatic adenocarcinoma
CVCL_1723 
Half Maximal Inhibitory Concentration (IC50) 304216.92 nM
LS-411N cells
Cecum adenocarcinoma
CVCL_1385 
Half Maximal Inhibitory Concentration (IC50) 305404.16 nM
no-11 cells
Glioblastoma
CVCL_3076 
Half Maximal Inhibitory Concentration (IC50) 30734.63 nM
HCC70 cells
Breast ductal carcinoma
CVCL_1270 
Half Maximal Inhibitory Concentration (IC50) 30883.87 nM
KYSE-520 cells
Esophageal squamous cell carcinoma
CVCL_1355 
Half Maximal Inhibitory Concentration (IC50) 309557.54 nM
MZ2-MEL cells
Melanoma
CVCL_1435 
Half Maximal Inhibitory Concentration (IC50) 309815.51 nM
RVH-421 cells
Melanoma
CVCL_1672 
Half Maximal Inhibitory Concentration (IC50) 311007.8 nM
P12-Ichikawa cells
T-cell leukemia
CVCL_1630 
Half Maximal Inhibitory Concentration (IC50) 31161.36 nM
JEG-3 cells
Gestational choriocarcinoma
CVCL_0363 
Half Maximal Inhibitory Concentration (IC50) 311679.06 nM
NCI-H1648 cells
Lung adenocarcinoma
CVCL_1482 
Half Maximal Inhibitory Concentration (IC50) 311898.56 nM
LNCaP-Clone-FGC cells
Prostate carcinoma
CVCL_1379 
Half Maximal Inhibitory Concentration (IC50) 31227.37 nM
C8166 cells
Leukemia
CVCL_1099 
Half Maximal Inhibitory Concentration (IC50) 312498.6 nM
HT-1197 cells
Recurrent bladder carcinoma
CVCL_1291 
Half Maximal Inhibitory Concentration (IC50) 312847.55 nM
Detroit 562 cells
Pharyngeal squamous cell carcinoma
CVCL_1171 
Half Maximal Inhibitory Concentration (IC50) 313853.09 nM
SK-LMS-1 cells
Vulvar leiomyosarcoma
CVCL_0628 
Half Maximal Inhibitory Concentration (IC50) 314103.96 nM
KYSE-510 cells
Esophageal squamous cell carcinoma
CVCL_1354 
Half Maximal Inhibitory Concentration (IC50) 314664.5 nM
23132-87 cells
Gastric adenocarcinoma
CVCL_1046 
Half Maximal Inhibitory Concentration (IC50) 314958.22 nM
VMRC-RCZ cells
Renal cell carcinoma
CVCL_1791 
Half Maximal Inhibitory Concentration (IC50) 316155.44 nM
KM-H2 cells
Hodgkin lymphoma
CVCL_1330 
Half Maximal Inhibitory Concentration (IC50) 31675.48 nM
SK-OV-3 cells
Ovarian serous adenocarcinoma
CVCL_0532 
Half Maximal Inhibitory Concentration (IC50) 317145.93 nM
CAL-120 cells
Breast carcinoma
CVCL_1104 
Half Maximal Inhibitory Concentration (IC50) 322065.52 nM
MHH-PREB-1 cells
B-cell non-Hodgkin lymphoma
CVCL_1413 
Half Maximal Inhibitory Concentration (IC50) 323528.43 nM
CAMA-1 cells
Breast adenocarcinoma
CVCL_1115 
Half Maximal Inhibitory Concentration (IC50) 324760.18 nM
KLE cells
Endometrial adenocarcinoma
CVCL_1329 
Half Maximal Inhibitory Concentration (IC50) 326450.39 nM
NCI-H2126 cells
Lung large cell carcinoma
CVCL_1532 
Half Maximal Inhibitory Concentration (IC50) 32683 nM
NCI-H526 cells
Lung small cell carcinoma
CVCL_1569 
Half Maximal Inhibitory Concentration (IC50) 327260.01 nM
SK-N-AS cells
Neuroblastoma
CVCL_1700 
Half Maximal Inhibitory Concentration (IC50) 328601.58 nM
A-375 cells
Amelanotic melanoma
CVCL_0132 
Half Maximal Inhibitory Concentration (IC50) 328877.39 nM
NCI-H1395 cells
Lung adenocarcinoma
CVCL_1467 
Half Maximal Inhibitory Concentration (IC50) 32956.78 nM
NKM-1 cells
Acute myeloid leukemia
CVCL_1607 
Half Maximal Inhibitory Concentration (IC50) 331379.75 nM
MC116 cells
B-cell non-Hodgkin lymphoma
CVCL_1399 
Half Maximal Inhibitory Concentration (IC50) 332521.33 nM
NCI-H446 cells
Lung small cell carcinoma
CVCL_1562 
Half Maximal Inhibitory Concentration (IC50) 332650.04 nM
DK-MG cells
Glioblastoma
CVCL_1173 
Half Maximal Inhibitory Concentration (IC50) 333820.69 nM
U-118-MG cells
Astrocytoma
CVCL_0633 
Half Maximal Inhibitory Concentration (IC50) 334498.7 nM
SW 962 cells
Vulva lymphoid carcinoma
CVCL_1733 
Half Maximal Inhibitory Concentration (IC50) 334912.06 nM
LU-99A cells
Lung giant cell carcinoma
CVCL_1393 
Half Maximal Inhibitory Concentration (IC50) 336203.29 nM
SW626 cells
Colon adenocarcinoma
CVCL_1725 
Half Maximal Inhibitory Concentration (IC50) 336662.18 nM
DU145 cells
Prostate carcinoma
CVCL_0105 
Half Maximal Inhibitory Concentration (IC50) 336665.21 nM
SK-MES-1 cells
Lung squamous cell carcinoma
CVCL_0630 
Half Maximal Inhibitory Concentration (IC50) 337526.49 nM
UACC-62 cells
Melanoma
CVCL_1780 
Half Maximal Inhibitory Concentration (IC50) 337779.06 nM
COLO-800 cells
Cutaneous melanoma
CVCL_1135 
Half Maximal Inhibitory Concentration (IC50) 338001.39 nM
DMS-79 cells
Small cell lung carcinoma
CVCL_1178 
Half Maximal Inhibitory Concentration (IC50) 341966.58 nM
GI-ME-N cells
Neuroblastoma
CVCL_1232 
Half Maximal Inhibitory Concentration (IC50) 342051.39 nM
TGBC11TKB cells
Gastric carcinoma
CVCL_1768 
Half Maximal Inhibitory Concentration (IC50) 344119.51 nM
MG-63 cells
Osteosarcoma
CVCL_0426 
Half Maximal Inhibitory Concentration (IC50) 344868.44 nM
OAW-42 cells
Ovarian serous cystadenocarcinoma
CVCL_1615 
Half Maximal Inhibitory Concentration (IC50) 34744.28 nM
ECC10 cells
Gastric small cell carcinoma
CVCL_1188 
Half Maximal Inhibitory Concentration (IC50) 349207.39 nM
H4 cells
Neuroglioma
CVCL_1239 
Half Maximal Inhibitory Concentration (IC50) 350015.7 nM
HCC1569 cells
Breast ductal carcinoma
CVCL_1255 
Half Maximal Inhibitory Concentration (IC50) 353050.82 nM
PFSK-1 cells
Primitive neuroectodermal tumor
CVCL_1642 
Half Maximal Inhibitory Concentration (IC50) 35360.06 nM
A2780 cells
Ovarian endometrioid adenocarcinoma
CVCL_0134 
Half Maximal Activity Concentration (AC50) 35481.3 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 354974.87 nM
SK-PN-DW cells
Primitive neuroectodermal tumor
CVCL_1703 
Half Maximal Inhibitory Concentration (IC50) 356776.67 nM
A-431 cells
Skin squamous cell carcinoma
CVCL_0037 
Half Maximal Inhibitory Concentration (IC50) 35768.08 nM
KY821 cells
Acute myelomonocytic leukemia
CVCL_1346 
Half Maximal Inhibitory Concentration (IC50) 359238.32 nM
MKN-28 cells
Gastric epithelial carcinoma
CVCL_1416 
Half Maximal Inhibitory Concentration (IC50) 360 nM
NAMALVA cells
Burkitt lymphoma
CVCL_0067 
Half Maximal Inhibitory Concentration (IC50) 3600 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 361759.64 nM
SNU-C2B cells
Cecum adenocarcinoma
CVCL_1710 
Half Maximal Inhibitory Concentration (IC50) 36213.72 nM
MKN-1 cells
Gastric carcinoma
CVCL_1415 
Half Maximal Inhibitory Concentration (IC50) 363167.8 nM
KYSE-140 cells
Esophageal squamous cell carcinoma
CVCL_1347 
Half Maximal Inhibitory Concentration (IC50) 364050.28 nM
SK-N-FI cells
Neuroblastoma
CVCL_1702 
Half Maximal Inhibitory Concentration (IC50) 365191.18 nM
RH-18 cells
Alveolar rhabdomyosarcoma
CVCL_1659 
Half Maximal Inhibitory Concentration (IC50) 366578.25 nM
NCI-H23 cells
Lung adenocarcinoma
CVCL_1547 
Half Maximal Inhibitory Concentration (IC50) 366581.55 nM
SBC-5 cells
Lung small cell carcinoma
CVCL_1679 
Half Maximal Inhibitory Concentration (IC50) 367622.28 nM
A549 cells
Lung adenocarcinoma
CVCL_0023 
Half Maximal Inhibitory Concentration (IC50) 368275.02 nM
LB2518-MEL cells
Melanoma
CVCL_1366 
Half Maximal Inhibitory Concentration (IC50) 369534.46 nM
DoTc2-4510 cells
Cervix uteri
CVCL_1181 
Half Maximal Inhibitory Concentration (IC50) 370292.41 nM
S-117 cells
Thyroid gland sarcoma
CVCL_1674 
Half Maximal Inhibitory Concentration (IC50) 371433.56 nM
P30-OHK cells
B acute lymphoblastic leukemia
CVCL_1631 
Half Maximal Inhibitory Concentration (IC50) 37421.22 nM
EKVX cells
Non-small cell lung carcinoma
CVCL_1195 
Half Maximal Inhibitory Concentration (IC50) 374456.26 nM
NCI-H1048 cells
Lung small cell carcinoma, Small cell lung cancer
CVCL_1453 
Half Maximal Inhibitory Concentration (IC50) 377275.99 nM
KURAMOCHI cells
Ovarian serous adenocarcinoma
CVCL_1345 
Half Maximal Inhibitory Concentration (IC50) 37800 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 380407.86 nM
ES6 cells
Ewing sarcoma
CVCL_1202 
Half Maximal Inhibitory Concentration (IC50) 383232.94 nM
8505C cells
Thyroid gland anaplastic carcinoma
CVCL_1054 
Half Maximal Inhibitory Concentration (IC50) 383449.14 nM
D-336MG cells
Glioblastoma
CVCL_1156 
Half Maximal Inhibitory Concentration (IC50) 38388.46 nM
EW-16 cells
Ewing sarcoma
CVCL_1212 
Half Maximal Inhibitory Concentration (IC50) 385316.09 nM
TI-73 cells
Normal
CVCL_3605 
Half Maximal Inhibitory Concentration (IC50) 386146.95 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 387335.79 nM
CP66-MEL cells
Melanoma
CVCL_1144 
Half Maximal Inhibitory Concentration (IC50) 388987.81 nM
MDA-MB-157 cells
Breast carcinoma
CVCL_0618 
Half Maximal Inhibitory Concentration (IC50) 390 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 390 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 390730.08 nM
NCI-H2452 cells
Pleural mesothelioma
CVCL_1553 
Half Maximal Inhibitory Concentration (IC50) 395131.65 nM
SW1573 cells
Lung carcinoma
CVCL_1720 
Half Maximal Inhibitory Concentration (IC50) 395202.78 nM
COLO-741 cells
Melanoma
CVCL_1133 
Half Maximal Inhibitory Concentration (IC50) 395511.16 nM
YKG-1 cells
Glioblastoma
CVCL_1796 
Half Maximal Inhibitory Concentration (IC50) 396426.64 nM
DSH1 cells
Bladder carcinoma
CVCL_1182 
Half Maximal Inhibitory Concentration (IC50) 396799.45 nM
PC-3 cells
Prostate carcinoma
CVCL_0035 
Half Maximal Inhibitory Concentration (IC50) 39778.95 nM
CTB-1 cells
Diffuse large B-cell lymphoma
CVCL_1149 
Half Maximal Inhibitory Concentration (IC50) 398786.03 nM
8-MG-BA cells
Glioblastoma
CVCL_1052 
Half Maximal Inhibitory Concentration (IC50) 398988.66 nM
NCI-H650 cells
Lung adenocarcinoma
CVCL_1575 
Half Maximal Inhibitory Concentration (IC50) 400951.31 nM
SHP-77 cells
Small cell lung carcinoma
CVCL_1693 
Half Maximal Inhibitory Concentration (IC50) 402258.13 nM
EW-1 cells
Ewing sarcoma
CVCL_1208 
Half Maximal Inhibitory Concentration (IC50) 403980.66 nM
LB1047-RCC cells
Renal cell carcinoma
CVCL_1364 
Half Maximal Inhibitory Concentration (IC50) 404342.38 nM
LB2241-RCC cells
Renal cell carcinoma
CVCL_1365 
Half Maximal Inhibitory Concentration (IC50) 40474.58 nM
COR-L105 cells
Lung adenocarcinoma
CVCL_1138 
Half Maximal Inhibitory Concentration (IC50) 406030.79 nM
DMS 114 cells
Lung small cell carcinoma
CVCL_1174 
Half Maximal Inhibitory Concentration (IC50) 407973.82 nM
OAW-28 cells
Ovarian serous cystadenocarcinoma
CVCL_1614 
Half Maximal Inhibitory Concentration (IC50) 408901.79 nM
AN3-CA cells
Endometrial adenocarcinoma
CVCL_0028 
Half Maximal Inhibitory Concentration (IC50) 409351.42 nM
CGTH-W-1 cells
Thyroid gland squamous cell carcinoma
CVCL_1120 
Half Maximal Inhibitory Concentration (IC50) 4105.15 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 41206.87 nM
SNU-5 cells
Gastric adenocarcinoma
CVCL_0078 
Half Maximal Inhibitory Concentration (IC50) 413029.91 nM
SiHa cells
Cervical squamous cell carcinoma
CVCL_0032 
Half Maximal Inhibitory Concentration (IC50) 413380.72 nM
BXPC-3 cells
Pancreatic ductal adenocarcinoma
CVCL_0186 
Half Maximal Inhibitory Concentration (IC50) 413644.95 nM
SJSA-1 cells
Osteosarcoma
CVCL_1697 
Half Maximal Inhibitory Concentration (IC50) 414069.15 nM
SW872 cells
Liposarcoma
CVCL_1730 
Half Maximal Inhibitory Concentration (IC50) 415629.4 nM
CAL-39 cells
Vulvar squamous cell carcinoma
CVCL_1109 
Half Maximal Inhibitory Concentration (IC50) 416526.46 nM
FTC-133 cells
Thyroid gland follicular carcinoma
CVCL_1219 
Half Maximal Inhibitory Concentration (IC50) 416624.36 nM
COLO-824 cells
Breast carcinoma
CVCL_1136 
Half Maximal Inhibitory Concentration (IC50) 419311.89 nM
MZ1-PC cells
Pancreatic ductal adenocarcinoma
CVCL_1434 
Half Maximal Inhibitory Concentration (IC50) 41987.08 nM
MeWo cells
Melanoma
CVCL_0445 
Half Maximal Inhibitory Concentration (IC50) 420784.15 nM
OCUB-M cells
Breast carcinoma
CVCL_1621 
Half Maximal Inhibitory Concentration (IC50) 421351.75 nM
NCI-H510A cells
Lung small cell carcinoma
CVCL_1565 
Half Maximal Inhibitory Concentration (IC50) 422143.79 nM
NCI-H727 cells
Lung carcinoid tumor
CVCL_1584 
Half Maximal Inhibitory Concentration (IC50) 422395.89 nM
UO-31 cells
Renal carcinoma
CVCL_1911 
Half Maximal Inhibitory Concentration (IC50) 423053.23 nM
MMAC-SF cells
Melanoma
CVCL_1420 
Half Maximal Inhibitory Concentration (IC50) 423203.44 nM
KYSE-150 cells
Esophageal squamous cell carcinoma, Squamous cell carcinoma of the esophagus
CVCL_1348 
Half Maximal Inhibitory Concentration (IC50) 425577.04 nM
D-423MG cells
Glioblastoma
CVCL_1160 
Half Maximal Inhibitory Concentration (IC50) 425701.33 nM
SCC-9 cells
Tongue squamous cell carcinoma
CVCL_1685 
Half Maximal Inhibitory Concentration (IC50) 428776.16 nM
M059J cells
Glioblastoma
CVCL_0400 
Half Maximal Inhibitory Concentration (IC50) 429000.03 nM
CAKI-1 cells
Clear cell renal cell carcinoma
CVCL_0234 
Half Maximal Inhibitory Concentration (IC50) 429079.84 nM
AU565 cells
Breast adenocarcinoma
CVCL_1074 
Half Maximal Inhibitory Concentration (IC50) 429670.66 nM
NTERA-2-cl-D1 cells
Teratocarcinoma
CVCL_3407 
Half Maximal Inhibitory Concentration (IC50) 434560.86 nM
NCI-H1581 cells
Lung large cell carcinoma
CVCL_1479 
Half Maximal Inhibitory Concentration (IC50) 435244.96 nM
SF-126 cells
Glioblastoma
CVCL_1688 
Half Maximal Inhibitory Concentration (IC50) 436266.81 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 436454.44 nM
GT3TKB cells
Lung squamous cell carcinoma
CVCL_1237 
Half Maximal Inhibitory Concentration (IC50) 437504.5 nM
EW-22 cells
Ewing sarcoma
CVCL_1214 
Half Maximal Inhibitory Concentration (IC50) 43791.69 nM
BCPAP cells
Thyroid carcinoma
CVCL_0153 
Half Maximal Inhibitory Concentration (IC50) 440074.05 nM
MFH-ino cells
Pleomorphic sarcoma
CVCL_1407 
Half Maximal Inhibitory Concentration (IC50) 440396.3 nM
LB831-BLC cells
Bladder carcinoma
CVCL_1370 
Half Maximal Inhibitory Concentration (IC50) 44277.6 nM
KARPAS-45 cells
T acute lymphoblastic leukemia
CVCL_1326 
Half Maximal Inhibitory Concentration (IC50) 444581.77 nM
MDA-MB-415 cells
Breast adenocarcinoma
CVCL_0621 
Half Maximal Inhibitory Concentration (IC50) 445770.84 nM
U251 cells
Astrocytoma
CVCL_0021 
Half Maximal Inhibitory Concentration (IC50) 446849.12 nM
RCM-1 cells
Rectal adenocarcinoma
CVCL_1648 
Half Maximal Inhibitory Concentration (IC50) 448982.99 nM
NCI-H460 cells
Lung large cell carcinoma
CVCL_0459 
Half Maximal Inhibitory Concentration (IC50) 449721.72 nM
NH-12 cells
Adrenal gland neuroblastoma
CVCL_1605 
Half Maximal Inhibitory Concentration (IC50) 455976.38 nM
NCI-H1755 cells
Lung adenocarcinoma
CVCL_1492 
Half Maximal Inhibitory Concentration (IC50) 462122.03 nM
LAN-6 cells
Neuroblastoma
CVCL_1363 
Half Maximal Inhibitory Concentration (IC50) 462464.13 nM
5637 cells
Bladder carcinoma
CVCL_0126 
Half Maximal Inhibitory Concentration (IC50) 463689.43 nM
MHH-ES-1 cells
Ewing sarcoma
CVCL_1411 
Half Maximal Inhibitory Concentration (IC50) 46698.64 nM
NCI-H1693 cells
Lung adenocarcinoma
CVCL_1488 
Half Maximal Inhibitory Concentration (IC50) 469051.23 nM
HCC1395 cells
Breast ductal carcinoma
CVCL_1249 
Half Maximal Inhibitory Concentration (IC50) 470132.23 nM
EFM-19 cells
Breast ductal carcinoma
CVCL_0253 
Half Maximal Inhibitory Concentration (IC50) 470143.52 nM
ES1 cells
Ewing sarcoma
CVCL_1198 
Half Maximal Inhibitory Concentration (IC50) 470433.68 nM
SW48 cells
Colon adenocarcinoma
CVCL_1724 
Half Maximal Inhibitory Concentration (IC50) 471361.35 nM
IGR-1 cells
Cutaneous melanoma
CVCL_1303 
Half Maximal Inhibitory Concentration (IC50) 472077.42 nM
GAK cells
Vulvar melanoma
CVCL_1225 
Half Maximal Inhibitory Concentration (IC50) 472445.79 nM
LXF-289 cells
Lung adenocarcinoma
CVCL_1394 
Half Maximal Inhibitory Concentration (IC50) 474468.87 nM
EC-GI-10 cells
Esophageal squamous cell carcinoma
CVCL_1187 
Half Maximal Inhibitory Concentration (IC50) 478265.01 nM
NCI-H2087 cells
Lung adenocarcinoma
CVCL_1524 
Half Maximal Inhibitory Concentration (IC50) 480 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 480216.96 nM
CAL-12T cells
Lung non-small cell carcinoma
CVCL_1105 
Half Maximal Inhibitory Concentration (IC50) 480530.64 nM
GI-1 cells
Gliosarcoma
CVCL_1231 
Half Maximal Inhibitory Concentration (IC50) 482258.37 nM
SCH cells
Gastric choriocarcinoma
CVCL_1687 
Half Maximal Inhibitory Concentration (IC50) 48322.44 nM
H-EMC-SS cells
Extraskeletal myxoid chondrosarcoma
CVCL_1238 
Half Maximal Inhibitory Concentration (IC50) 487674.9 nM
no-10 cells
Glioblastoma
CVCL_3075 
Half Maximal Inhibitory Concentration (IC50) 495916.72 nM
MC-IXC cells
Askin tumor
CVCL_1398 
Half Maximal Inhibitory Concentration (IC50) 499073.31 nM
NCI-H747 cells
Cecum adenocarcinoma
CVCL_1587 
Half Maximal Inhibitory Concentration (IC50) 50 nM
MM1.S cells
Plasma cell myeloma, Multiple myeloma
CVCL_8792 
Half Maximal Inhibitory Concentration (IC50) 502690.16 nM
Calu-3 cells
Lung adenocarcinoma
CVCL_0609 
Half Maximal Inhibitory Concentration (IC50) 502964.71 nM
MCF-7 cells
Invasive breast carcinoma of no special type
CVCL_0031 
Half Maximal Inhibitory Concentration (IC50) 50354.5 nM
697 cells
Childhood B acute lymphoblastic leukemia
CVCL_0079 
Half Maximal Inhibitory Concentration (IC50) 508046.51 nM
COLO-678 cells
Colon carcinoma
CVCL_1129 
Half Maximal Inhibitory Concentration (IC50) 509950.67 nM
RO82-W-1 cells
Thyroid gland follicular carcinoma
CVCL_0582 
Half Maximal Inhibitory Concentration (IC50) 510901.6 nM
NCI-H2347 cells
Lung adenocarcinoma
CVCL_1550 
Half Maximal Inhibitory Concentration (IC50) 511827.68 nM
OVCAR-4 cells
Ovarian adenocarcinoma
CVCL_1627 
Half Maximal Inhibitory Concentration (IC50) 514105.76 nM
EW-24 cells
Ewing sarcoma
CVCL_1215 
Half Maximal Inhibitory Concentration (IC50) 516153.91 nM
Huh-7 cells
Adult hepatocellular carcinoma
CVCL_0336 
Half Maximal Inhibitory Concentration (IC50) 5190 nM
HEK293 cells
Normal
CVCL_0045 
Half Maximal Inhibitory Concentration (IC50) 5190 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 519501.66 nM
SNU-449 cells
Hepatocellular carcinoma
CVCL_0454 
Half Maximal Inhibitory Concentration (IC50) 521345.52 nM
ES7 cells
Ewing sarcoma
CVCL_1203 
Half Maximal Inhibitory Concentration (IC50) 521924.01 nM
SH-4 cells
Melanoma
CVCL_1692 
Half Maximal Inhibitory Concentration (IC50) 52314.16 nM
KP-N-YS cells
Adrenal gland neuroblastoma
CVCL_1342 
Half Maximal Inhibitory Concentration (IC50) 524688.63 nM
SCC-25 cells
Squamous carcinoma
CVCL_1682 
Half Maximal Inhibitory Concentration (IC50) 52702.35 nM
NCI-H1304 cells
Lung small cell carcinoma
CVCL_1462 
Half Maximal Inhibitory Concentration (IC50) 52855.88 nM
NOS-1 cells
Osteosarcoma
CVCL_1610 
Half Maximal Effective Concentration (EC50) 53 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 530106.54 nM
SK-HEP-1 cells
Liver and intrahepatic bile duct epithelial neoplasm
CVCL_0525 
Half Maximal Inhibitory Concentration (IC50) 53050.75 nM
NCI-H2342 cells
Lung adenocarcinoma
CVCL_1549 
Half Maximal Inhibitory Concentration (IC50) 533327.14 nM
NCI-H1623 cells
Lung adenocarcinoma
CVCL_1481 
Half Maximal Inhibitory Concentration (IC50) 53636.4 nM
KYSE-270 cells
Esophageal squamous cell carcinoma
CVCL_1350 
Half Maximal Inhibitory Concentration (IC50) 536709.51 nM
D-247MG cells
Gliosarcoma
CVCL_1153 
Half Maximal Inhibitory Concentration (IC50) 538775.52 nM
TE-8 cells
Esophageal squamous cell carcinoma
CVCL_1766 
Half Maximal Inhibitory Concentration (IC50) 539583.75 nM
CAL-51 cells
Breast carcinoma
CVCL_1110 
Half Maximal Inhibitory Concentration (IC50) 539742.41 nM
G-401 cells
Kidney Wilm's tumor
CVCL_0270 
Half Maximal Inhibitory Concentration (IC50) 540721.31 nM
T84 cells
Colon adenocarcinoma
CVCL_0555 
Half Maximal Inhibitory Concentration (IC50) 541373.27 nM
MKN7 cells
Gastric tubular adenocarcinoma
CVCL_1417 
Half Maximal Inhibitory Concentration (IC50) 542468.49 nM
OE19 cells
Esophageal adenocarcinoma
CVCL_1622 
Half Maximal Inhibitory Concentration (IC50) 542770.73 nM
KNS-42 cells
Glioblastoma
CVCL_0378 
Half Maximal Inhibitory Concentration (IC50) 543070.42 nM
HSC-2 cells
Oral cavity squamous cell carcinoma
CVCL_1287 
Half Maximal Inhibitory Concentration (IC50) 545081.87 nM
OVCAR-5 cells
Ovarian serous adenocarcinoma
CVCL_1628 
Half Maximal Inhibitory Concentration (IC50) 547792.19 nM
SW780 cells
Mouse melanoma
CVCL_1728 
Half Maximal Inhibitory Concentration (IC50) 548575 nM
SW1783 cells
Anaplastic astrocytoma
CVCL_1722 
Half Maximal Inhibitory Concentration (IC50) 55185.27 nM
LU-135 cells
Lung small cell carcinoma
CVCL_1389 
Half Maximal Inhibitory Concentration (IC50) 553856.71 nM
LK-2 cells
Lung squamous cell carcinoma
CVCL_1377 
Half Maximal Inhibitory Concentration (IC50) 554057.79 nM
RERF-LC-MS cells
Lung adenocarcinoma
CVCL_1655 
Half Maximal Inhibitory Concentration (IC50) 555300.27 nM
BB49-HNC cells
Floor of mouth squamous cell carcinoma
CVCL_1077 
Half Maximal Inhibitory Concentration (IC50) 557158.63 nM
T98G cells
Glioblastoma
CVCL_0556 
Half Maximal Inhibitory Concentration (IC50) 557379.87 nM
MFM-223 cells
Breast carcinoma
CVCL_1408 
Half Maximal Inhibitory Concentration (IC50) 558055.82 nM
EFO-21 cells
Ovarian serous cystadenocarcinoma
CVCL_0029 
Half Maximal Inhibitory Concentration (IC50) 55817.98 nM
OE33 cells
Barrett adenocarcinoma, Adenocarcinoma of the esophagus
CVCL_0471 
Half Maximal Inhibitory Concentration (IC50) 55948.86 nM
ML-2 cells
Acute myeloid leukemia
CVCL_1418 
Half Maximal Inhibitory Concentration (IC50) 559787.36 nM
SNB-75 cells
Glioblastoma
CVCL_1706 
Half Maximal Inhibitory Concentration (IC50) 562242.92 nM
KU-19-19 cells
Bladder carcinoma
CVCL_1344 
Half Maximal Inhibitory Concentration (IC50) 562576.99 nM
NCI-H2052 cells
Pleural mesothelioma
CVCL_1518 
Half Maximal Inhibitory Concentration (IC50) 56289.27 nM
KMOE-2 cells
Erythroleukemia
CVCL_1332 
Half Maximal Inhibitory Concentration (IC50) 56320.41 nM
Daoy cells
Medulloblastoma
CVCL_1167 
Half Maximal Inhibitory Concentration (IC50) 563670.01 nM
M14 cells
Melanoma
CVCL_1395 
Half Maximal Inhibitory Concentration (IC50) 564896.77 nM
RPMI-2650 cells
Head and neck squamous cell carcinoma
CVCL_1664 
Half Maximal Inhibitory Concentration (IC50) 567019.11 nM
KP-N-YN cells
Adrenal gland neuroblastoma
CVCL_1341 
Half Maximal Inhibitory Concentration (IC50) 57014.24 nM
KNS-62 cells
Lung squamous cell carcinoma
CVCL_1335 
Half Maximal Inhibitory Concentration (IC50) 573182.98 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 573459.89 nM
TYK-nu cells
Ovarian serous adenocarcinoma
CVCL_1776 
Half Maximal Inhibitory Concentration (IC50) 573524.7 nM
NCI-H441 cells
Lung papillary adenocarcinoma
CVCL_1561 
Half Maximal Inhibitory Concentration (IC50) 575590.23 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 57570.48 nM
NBsusSR cells
Neuroblastoma
CVCL_1450 
Half Maximal Inhibitory Concentration (IC50) 575992.13 nM
SAOS-2 cells
Osteosarcoma
CVCL_0548 
Half Maximal Inhibitory Concentration (IC50) 577415.44 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 579161.87 nM
DMS-273 cells
Small cell lung carcinoma
CVCL_1176 
Half Maximal Inhibitory Concentration (IC50) 580818.32 nM
CAL-62 cells
Thyroid gland anaplastic carcinoma
CVCL_1112 
Half Maximal Inhibitory Concentration (IC50) 581027.45 nM
TE-5 cells
Esophageal squamous cell carcinoma
CVCL_1764 
Half Maximal Inhibitory Concentration (IC50) 581448.27 nM
LS1034 cells
Cecum adenocarcinoma
CVCL_1382 
Half Maximal Inhibitory Concentration (IC50) 582737.6 nM
A704 cells
Renal carcinoma
CVCL_1065 
Half Maximal Inhibitory Concentration (IC50) 583388.3 nM
TE-6 cells
Esophageal squamous cell carcinoma
CVCL_1765 
Half Maximal Inhibitory Concentration (IC50) 585491.7 nM
C3A cells
Hepatoblastoma
CVCL_1098 
Half Maximal Inhibitory Concentration (IC50) 58626.39 nM
UACC-257 cells
Melanoma
CVCL_1779 
Half Maximal Inhibitory Concentration (IC50) 58825.95 nM
LU-139 cells
Lung small cell carcinoma
CVCL_1390 
Half Maximal Inhibitory Concentration (IC50) 58864.31 nM
CAL-85-1 cells
Breast carcinoma
CVCL_1114 
Half Maximal Inhibitory Concentration (IC50) 58894.16 nM
NCI-H720 cells
Lung carcinoid tumor
CVCL_1583 
Half Maximal Inhibitory Concentration (IC50) 589025.81 nM
SW1417 cells
Colon adenocarcinoma
CVCL_1717 
Half Maximal Inhibitory Concentration (IC50) 589140.68 nM
SNU-423 cells
Hepatocellular carcinoma
CVCL_0366 
Half Maximal Inhibitory Concentration (IC50) 59090.96 nM
MLMA cells
Hairy cell leukemia
CVCL_1419 
Half Maximal Inhibitory Concentration (IC50) 59280.89 nM
A3-KAW cells
Diffuse large B-cell lymphoma
CVCL_1062 
Half Maximal Inhibitory Concentration (IC50) 592887.1 nM
KNS-81-FD cells
Glioblastoma
CVCL_1336 
Half Maximal Inhibitory Concentration (IC50) 594199.43 nM
SKG-IIIa cells
Cervical squamous cell carcinoma
CVCL_1704 
Half Maximal Inhibitory Concentration (IC50) 59628.7 nM
Ramos-2G6-4C10 cells
Burkitt lymphoma
CVCL_1646 
Half Maximal Inhibitory Concentration (IC50) 60449 nM
A388 cells
Skin squamous cell carcinoma
CVCL_1063 
Half Maximal Inhibitory Concentration (IC50) 606341.89 nM
Capan-2 cells
Pancreatic ductal adenocarcinoma
CVCL_0026 
Half Maximal Inhibitory Concentration (IC50) 606429.81 nM
NCI-H1651 cells
Lung adenocarcinoma
CVCL_1484 
Half Maximal Inhibitory Concentration (IC50) 606492.28 nM
MEL-HO cells
Melanoma
CVCL_1402 
Half Maximal Inhibitory Concentration (IC50) 60990.49 nM
LAMA-84 cells
Chronic myeloid leukemia
CVCL_0388 
Half Maximal Inhibitory Concentration (IC50) 610471.13 nM
CW-2 cells
Colon adenocarcinoma
CVCL_1151 
Half Maximal Inhibitory Concentration (IC50) 61078.63 nM
GCT cells
Pleomorphic sarcoma
CVCL_1229 
Half Maximal Inhibitory Concentration (IC50) 61533.33 nM
K562 cells
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive, Chronic myeloid leukemia
CVCL_0004 
Half Maximal Inhibitory Concentration (IC50) 615376.33 nM
SF268 cells
Astrocytoma
CVCL_1689 
Half Maximal Inhibitory Concentration (IC50) 618379.9 nM
C-33-A cells
Cervical squamous cell carcinoma
CVCL_1094 
Half Maximal Inhibitory Concentration (IC50) 61875.05 nM
NCI-H1666 cells
Lung adenocarcinoma
CVCL_1485 
Half Maximal Inhibitory Concentration (IC50) 618929.27 nM
U-87MG ATCC cells
Glioblastoma
CVCL_0022 
Half Maximal Inhibitory Concentration (IC50) 6218.49 nM
BT-549 cells
Breast ductal carcinoma
CVCL_1092 
Half Maximal Inhibitory Concentration (IC50) 622110.67 nM
TE-10 cells
Esophageal squamous cell carcinoma
CVCL_1760 
Half Maximal Inhibitory Concentration (IC50) 624277.51 nM
CAS-1 cells
Glioblastoma
CVCL_1117 
Half Maximal Inhibitory Concentration (IC50) 627423.66 nM
NB5 cells
Neuroblastoma
CVCL_8822 
Half Maximal Activity Concentration (AC50) 631 nM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) 631 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 63404.26 nM
NCI-H1993 cells
Lung adenocarcinoma
CVCL_1512 
Half Maximal Inhibitory Concentration (IC50) 638442.11 nM
NCI-H596 cells
Lung adenosquamous carcinoma
CVCL_1571 
Half Maximal Inhibitory Concentration (IC50) 639351.9 nM
LS-513 cells
Cecum adenocarcinoma
CVCL_1386 
Half Maximal Inhibitory Concentration (IC50) 645474.04 nM
NCI-H520 cells
Lung squamous cell carcinoma
CVCL_1566 
Half Maximal Inhibitory Concentration (IC50) 647115.63 nM
SF539 cells
Gliosarcoma
CVCL_1691 
Half Maximal Inhibitory Concentration (IC50) 65012.14 nM
NCI-H358 cells
Minimally invasive lung adenocarcinoma
CVCL_1559 
Half Maximal Inhibitory Concentration (IC50) 650619.51 nM
MDA-MB-453 cells
Breast adenocarcinoma
CVCL_0418 
Half Maximal Inhibitory Concentration (IC50) 650890.87 nM
RH-1 cells
Ewing sarcoma
CVCL_1658 
Half Maximal Inhibitory Concentration (IC50) 651697.18 nM
SNU-387 cells
Hepatocellular carcinoma
CVCL_0250 
Half Maximal Inhibitory Concentration (IC50) 653676.77 nM
LCLC-97TM1 cells
Lung large cell carcinoma
CVCL_1376 
Half Maximal Inhibitory Concentration (IC50) 659655.02 nM
HT-3 cells
Cervical carcinoma
CVCL_1293 
Half Maximal Inhibitory Concentration (IC50) 659665.57 nM
Hs578T cells
Invasive breast carcinoma of no special type
CVCL_0332 
Half Maximal Inhibitory Concentration (IC50) 65988.01 nM
NB6 cells
Neuroblastoma
CVCL_8823 
Half Maximal Inhibitory Concentration (IC50) 662944.32 nM
NB12 cells
Neuroblastoma
CVCL_1442 
Half Maximal Effective Concentration (EC50) 67 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 67079.8 nM
HCE-T cells
Nornal
CVCL_1272 
Half Maximal Inhibitory Concentration (IC50) 671307.97 nM
NCI-H2291 cells
Lung adenocarcinoma
CVCL_1546 
Half Maximal Inhibitory Concentration (IC50) 67494.76 nM
DOK cells
Oral epithelial dysplasia
CVCL_1180 
Half Maximal Inhibitory Concentration (IC50) 675539.75 nM
SW1710 cells
Bladder carcinoma
CVCL_1721 
Half Maximal Inhibitory Concentration (IC50) 678532.24 nM
OMC-1 cells
Cervical squamous cell carcinoma
CVCL_1623 
Half Maximal Inhibitory Concentration (IC50) 679450.24 nM
CP50-MEL-B cells
Melanoma
CVCL_1143 
Half Maximal Inhibitory Concentration (IC50) 681929.31 nM
COLO-679 cells
Cutaneous melanoma
CVCL_1130 
Half Maximal Inhibitory Concentration (IC50) 696363.64 nM
COR-L23 cells
Lung carcinoma
CVCL_1139 
Half Maximal Inhibitory Concentration (IC50) 69831.42 nM
HT-1376 cells
Bladder carcinoma
CVCL_1292 
Half Maximal Effective Concentration (EC50) 70 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 70.17 nM
MM1.S cells
Plasma cell myeloma, Multiple myeloma
CVCL_8792 
Half Maximal Inhibitory Concentration (IC50) 70124.34 nM
NEC8 cells
Testicular embryonal carcinoma
CVCL_1604 
Half Maximal Inhibitory Concentration (IC50) 703905.42 nM
YAPC cells
Pancreas carincoma
CVCL_1794 
Half Maximal Inhibitory Concentration (IC50) 70939.47 nM
G-402 cells
Kidney neoplasm
CVCL_1221 
Half Maximal Inhibitory Concentration (IC50) 71172.04 nM
GR-ST cells
B acute lymphoblastic leukemia
CVCL_1236 
Half Maximal Inhibitory Concentration (IC50) 71443.43 nM
QIMR-WIL cells
Acute myeloid leukemia
CVCL_1645 
Half Maximal Inhibitory Concentration (IC50) 71965.01 nM
CHP-212 cells
Neuroblastoma
CVCL_1125 
Half Maximal Inhibitory Concentration (IC50) 724424.1 nM
SW684 cells
Fibrosarcoma
CVCL_1726 
Half Maximal Inhibitory Concentration (IC50) 729007.49 nM
GMS-10 cells
Glioblastoma
CVCL_1233 
Half Maximal Inhibitory Concentration (IC50) 72970.19 nM
KU812 cells
Chronic myeloid leukemia
CVCL_0379 
Half Maximal Inhibitory Concentration (IC50) 730250.77 nM
MDA-MB-175-VII cells
Invasive breast carcinoma of no special type
CVCL_1400 
Half Maximal Inhibitory Concentration (IC50) 73148.89 nM
Becker cells
Astrocytoma
CVCL_1093 
Half Maximal Inhibitory Concentration (IC50) 734873.22 nM
8305C cells
Thyroid gland anaplastic carcinoma
CVCL_1053 
Half Maximal Inhibitory Concentration (IC50) 74748.56 nM
ChaGo-K-1 cells
Bronchogenic carcinoma
CVCL_1121 
Half Maximal Inhibitory Concentration (IC50) 74930.8 nM
A498 cells
Renal carcinoma
CVCL_1056 
Half Maximal Inhibitory Concentration (IC50) 753326.7 nM
TE-9 cells
Esophageal squamous cell carcinoma
CVCL_1767 
Half Maximal Inhibitory Concentration (IC50) 75766.33 nM
NCI-H69 cells
Lung small cell carcinoma, Small cell lung cancer
CVCL_1579 
Half Maximal Inhibitory Concentration (IC50) 760228.47 nM
EPLC-272H cells
Lung mucoepidermoid carcinoma
CVCL_1197 
Half Maximal Inhibitory Concentration (IC50) 778266.49 nM
HT55 cells
Rectal adenocarcinoma
CVCL_1294 
Half Maximal Inhibitory Concentration (IC50) 78614.72 nM
NCI-H209 cells
Lung small cell carcinoma
CVCL_1525 
Half Maximal Inhibitory Concentration (IC50) 7895.12 nM
SK-NEP-1 cells
Ewing sarcoma
CVCL_0631 
Half Maximal Inhibitory Concentration (IC50) 78993.85 nM
CAL-33 cells
Squamous cell carcinoma of the oral tongue, Tongue squamous cell carcinoma
CVCL_1108 
Half Maximal Inhibitory Concentration (IC50) 79100.72 nM
COLO-680N cells
Esophageal squamous cell carcinoma
CVCL_1131 
Half Maximal Activity Concentration (AC50) 7943.3 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 79812.01 nM
D283 Med cells
Medulloblastoma
CVCL_1155 
Half Maximal Inhibitory Concentration (IC50) 81 nM
MM1.S cells
Plasma cell myeloma, Multiple myeloma
CVCL_8792 
Half Maximal Inhibitory Concentration (IC50) 81 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 81118.74 nM
ATN-1 cells
T acute lymphoblastic leukemia
CVCL_1073 
Half Maximal Inhibitory Concentration (IC50) 81729.58 nM
NCI-N87 cells
Gastric tubular adenocarcinoma
CVCL_1603 
Half Maximal Inhibitory Concentration (IC50) 81884.93 nM
MHH-NB-11 cells
Neuroblastoma
CVCL_1412 
Half Maximal Inhibitory Concentration (IC50) 821382.59 nM
HCC38 cells
Breast ductal carcinoma
CVCL_1267 
Half Maximal Inhibitory Concentration (IC50) 82413.4 nM
HEL cells
Erythroleukemia
CVCL_0001 
Half Maximal Inhibitory Concentration (IC50) 83003.35 nM
NB69 cells
Neuroblastoma
CVCL_1448 
Half Maximal Inhibitory Concentration (IC50) 83257.48 nM
MPP-89 cells
Pleural epithelioid mesothelioma
CVCL_1427 
Half Maximal Inhibitory Concentration (IC50) 85491.25 nM
COLO-829 cells
Cutaneous melanoma
CVCL_1137 
Half Maximal Inhibitory Concentration (IC50) 85790.82 nM
ONS-76 cells
Medulloblastoma
CVCL_1624 
Half Maximal Inhibitory Concentration (IC50) 86203.17 nM
EW-3 cells
Ewing sarcoma
CVCL_1216 
Half Maximal Inhibitory Concentration (IC50) 86433.64 nM
EW-11 cells
Ewing sarcoma
CVCL_1209 
Half Maximal Inhibitory Concentration (IC50) 8675.85 nM
BV-173 cells
Chronic myelogenous leukemia
CVCL_0181 
Half Maximal Effective Concentration (EC50) 87 nM Undisclosed Undisclosed Undisclosed
Half Maximal Inhibitory Concentration (IC50) 87205.29 nM
SW900 cells
Lung squamous cell carcinoma
CVCL_1731 
Half Maximal Inhibitory Concentration (IC50) 87224.3 nM
MOLT-13 cells
T acute lymphoblastic leukemia
CVCL_1422 
Half Maximal Inhibitory Concentration (IC50) 88.99 nM Undisclosed Undisclosed Undisclosed
Half Maximal Degradation Concentration (DC50) 90 nM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
Half Maximal Inhibitory Concentration (IC50) 91040.46 nM
HuP-T4 cells
Pancreatic adenocarcinoma
CVCL_1300 
Half Maximal Inhibitory Concentration (IC50) 91637.36 nM
HCC1419 cells
Breast ductal carcinoma
CVCL_1251 
Half Maximal Inhibitory Concentration (IC50) 92021.94 nM
CAL-72 cells
Osteosarcoma
CVCL_1113 
Half Maximal Inhibitory Concentration (IC50) 92769.69 nM
Cancer cells
Multiple myeloma, Plasma cell myeloma
Undisclosed
Half Maximal Inhibitory Concentration (IC50) 92882.1 nM
OC-314 cells
Ovarian serous adenocarcinoma
CVCL_1616 
Half Maximal Inhibitory Concentration (IC50) 93099.98 nM
BHT-101 cells
Anaplastic thyroid carcinoma
CVCL_1085 
Half Maximal Inhibitory Concentration (IC50) 93846.17 nM
EW-18 cells
Ewing sarcoma
CVCL_1213 
Half Maximal Inhibitory Concentration (IC50) 94305.45 nM
TE-12 cells
Esophageal squamous cell carcinoma
CVCL_1762 
Half Maximal Inhibitory Concentration (IC50) 96051.55 nM
MDA-MB-361 cells
Breast adenocarcinoma
CVCL_0620 
Half Maximal Activity Concentration (AC50) 0.631 uM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) 0.631 uM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) 1.259 uM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) 1.778 uM Undisclosed Undisclosed Undisclosed
Half Maximal Degradation Concentration (DC50) >10 uM
K562 cells
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive, Chronic myeloid leukemia
CVCL_0004 
Half Maximal Degradation Concentration (DC50) >10 uM
MOLT-4 cells
Adult T acute lymphoblastic leukemia
CVCL_0013 
Half Maximal Activity Concentration (AC50) 35.48 uM Undisclosed Undisclosed Undisclosed
Half Maximal Activity Concentration (AC50) 7.943 uM Undisclosed Undisclosed Undisclosed
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
TE-1146 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.45 uM
High CD38 expression (CD38 +++)
Method Description
To evaluate the cytotoxic effects of various drugs, H929, U266-CD38-, MM.1S, and Daudi cells were seeded at 5000 cells per well in 96-well plates and cocultured with fresh medium containing different drug concentrations for varying durations (5 h, 1 day, 3 or 5 days) at 37 °C. Cell viability was determined using the alamarBlue cell viability reagent (Thermo Fisher Scientific). About 10 uL alamarBlue cell viability reagent was added to achieve a final concentration of 10% v/v and incubated at 37 °C for 1.5 h. The fluorescence was measured on a microplate reader in arbitrary fluorescent units following excitation at 560 nm and emission at 590 nm.

   Click to Show/Hide
In Vitro Model Multiple myeloma, Plasma cell myeloma H929 cells CVCL_1600
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.45 uM
High CD38 expression (CD38 +++)
Method Description
To evaluate the cytotoxic effects of various drugs, H929, U266-CD38-, MM.1S, and Daudi cells were seeded at 5000 cells per well in 96-well plates and cocultured with fresh medium containing different drug concentrations for varying durations (5 h, 1 day, 3 or 5 days) at 37 °C. Cell viability was determined using the alamarBlue cell viability reagent (Thermo Fisher Scientific). About 10 uL alamarBlue cell viability reagent was added to achieve a final concentration of 10% v/v and incubated at 37 °C for 1.5 h. The fluorescence was measured on a microplate reader in arbitrary fluorescent units following excitation at 560 nm and emission at 590 nm.

   Click to Show/Hide
In Vitro Model Plasma cell myeloma, Multiple myeloma MM.1S cells CVCL_8792
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) > 10000 uM Negative CD38 expression (CD38-)
Method Description
To evaluate the cytotoxic effects of various drugs, H929, U266-CD38-, MM.1S, and Daudi cells were seeded at 5000 cells per well in 96-well plates and cocultured with fresh medium containing different drug concentrations for varying durations (5 h, 1 day, 3 or 5 days) at 37 °C. Cell viability was determined using the alamarBlue cell viability reagent (Thermo Fisher Scientific). About 10 uL alamarBlue cell viability reagent was added to achieve a final concentration of 10% v/v and incubated at 37 °C for 1.5 h. The fluorescence was measured on a microplate reader in arbitrary fluorescent units following excitation at 560 nm and emission at 590 nm.

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In Vitro Model Multiple myeloma, Plasma cell myeloma U266 (CD38-) cells Homo sapiens
References
Ref 1 An Antibody-Drug Conjugate for Multiple Myeloma Prepared by Multi-Arm Linkers