Payload Information
General Information of This Payload
| Payload ID | PAY0NESLG |
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|---|---|---|---|---|---|---|
| Name | 2-DDDX-d |
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| Synonyms |
2-DDDX-d
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| Target(s) | DNA topoisomerase 1 (TOP1) | |||||
| Structure |
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| Formula | C26H24FN3O6 |
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| Isosmiles | [H]OC([2H])([2H])C(=O)N([H])[C@]1([H])c2c3c(nc4c([H])c(F)c(C([H])([H])[H])c(c24)C([H])([H])C1([H])[H])-c1c([H])c2c(c(=O)n1C3([H])[H])C([H])([H])OC(=O)[C@]2(O[H])C([H])([H])C([H])([H])[H] |
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| InChI |
InChI=1S/C26H24FN3O6/c1-3-26(35)15-6-19-23-13(8-30(19)24(33)14(15)10-36-25(26)34)22-17(28-20(32)9-31)5-4-12-11(2)16(27)7-18(29-23)21(12)22/h6-7,17,31,35H,3-5,8-10H2,1-2H3,(H,28,32)/t17-,26-/m0/s1/i9D2
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| InChIKey |
PLXLYXLUCNZSAA-SEPCXYQLSA-N
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| Pharmaceutical Properties | Molecule Weight |
495.5032036 |
Polar area |
130.75 |
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Complexity |
495.1774672 |
xlogp Value |
1.62292 |
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Heavy Count |
36 |
Rot Bonds |
7 |
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Hbond acc |
8 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
TQB2102 [Phase 2]
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Related Clinical Trial | |||||
| NCT Number | NCT05735496 | Phase Status | Phase 1 | ||
| Clinical Description |
A phase 1 study of TQB2102 injection in patients with advanced cancers.
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