Payload Information
General Information of This Payload
| Payload ID | PAY0MKGRB |
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| Name | U-003 |
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| Synonyms |
U-003
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| Target | Microtubule (MT) | |||||
| Formula | C27H27FN4O5 |
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| Isosmiles | O=C(N[C@H]1CC2=C3C(C1)=C4C(C(N(C5=O)C4)=CC([C@@]6(O)CC)=C5COC6=O)=NC3=CC(F)=C2C)CNC |
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| InChI |
InChI=1S/C27H27FN4O5/c1-4-27(36)18-7-21-24-16(10-32(21)25(34)17(18)11-37-26(27)35)15-6-13(30-22(33)9-29-3)5-14-12(2)19(28)8-20(31-24)23(14)15/h7-8,13,29,36H,4-6,9-11H2,1-3H3,(H,30,33)/t13-,27-/m0/s1
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| InChIKey |
PNDXMYJWJDHLDJ-CEXHIMGSSA-N
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| Pharmaceutical Properties | Molecule Weight |
506.534 |
Polar area |
122.55 |
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Complexity |
1551.86507 |
xlogp Value |
1.32992 |
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Heavy Count |
37 |
Rot Bonds |
4 |
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Hbond acc |
8 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
aU2023279443A1 Example A4 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) | > 100% | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
A mixed solvent of PBS and and Matrigel was used to prepare a cell suspension of 5.0x107 cells / mL. The prepared cell suspension was subcutaneously injected to the right flank region of female BALB/c-nu/nu mice at 0.1 mL per mouse. Individuals having a tumor volume within a range of 50 to 500 mm 3 were selected. test compound at a concentration of 3 mg/kg or the solvent alone was intravenously administered. the tumor volume was measured at Day 0 and Day 21.
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| In Vivo Model | NCI-N87 female BALB/c-nu/nu mice model | ||||