Payload Information
General Information of This Payload
| Payload ID | PAY0LWTQQ |
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| Name | NMS-P945 |
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| Synonyms |
NMS-P945
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| Target(s) | Human Deoxyribonucleic acid (hDNA) | |||||
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
CDX-0125-TEI [Investigative]
Discovered Using Patient-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 10.13% (Day 15) | Positive ALK expression (ALK+++/++) | ||
| Method Description |
The in vivo efficacy of CDX-0125-TEI was evaluated in female CB17 SCID mice bearing COG-N-424x (ALK wild-type). Upon enrollment, mice (n = 10 per group) were intraperitoneally injected with 10 mg/kg CDX-0125-TE on day 0 of enrollment and on day 7.
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| In Vivo Model | Neuroblastoma PDX model (PDX: COG-N-424x) | ||||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 15.15% (Day 21) | Moderate ALK expression (ALK++) | ||
| Method Description |
Mice (n = 10 per group) were intraperitoneally injected with the following drugs: IgG, unconjugated CDX-0125, or CDX-0125-TEI once a week for two consecutive weeks at a range of doses 1 mg/kg.
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| In Vivo Model | Neuroblastoma PDX model (PDX: ALK F1174L) | ||||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 39.21% (Day 19) | Positive ALK expression (ALK+++/++) | ||
| Method Description |
Mice (n = 10 per group) were intraperitoneally injected with the following drugs: IgG, unconjugated CDX-0125, or CDX-0125-TEI once a week for two consecutive weeks at a range of doses 1 mg/kg.
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| In Vivo Model | Neuroblastoma PDX model (PDX: ALK F1245C) | ||||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 44.99% (Day 19) | Positive ALK expression (ALK+++/++) | ||
| Method Description |
Mice (n = 10 per group) were intraperitoneally injected with the following drugs: IgG, unconjugated CDX-0125, or CDX-0125-TEI once a week for two consecutive weeks at a range of doses 3 mg/kg.
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| In Vivo Model | Neuroblastoma PDX model (PDX: ALK F1245C) | ||||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 54.55% (Day 21) | Moderate ALK expression (ALK++) | ||
| Method Description |
Mice (n = 10 per group) were intraperitoneally injected with the following drugs: IgG, unconjugated CDX-0125, or CDX-0125-TEI once a week for two consecutive weeks at a range of doses 3 mg/kg.
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| In Vivo Model | Neuroblastoma PDX model (PDX: ALK F1174L) | ||||
| Experiment 6 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 71.66% (Day 21) | Moderate ALK expression (ALK++) | ||
| Method Description |
Mice (n = 10 per group) were intraperitoneally injected with the following drugs: IgG, unconjugated CDX-0125, or CDX-0125-TEI once a week for two consecutive weeks at a range of doses 10 mg/kg.
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| In Vivo Model | Neuroblastoma PDX model (PDX: ALK F1174L) | ||||
| Experiment 7 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 85.83% (Day 19) | Positive ALK expression (ALK+++/++) | ||
| Method Description |
Mice (n = 10 per group) were intraperitoneally injected with the following drugs: IgG, unconjugated CDX-0125, or CDX-0125-TEI once a week for two consecutive weeks at a range of doses 10 mg/kg.
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| In Vivo Model | Neuroblastoma PDX model (PDX: ALK F1245C) | ||||
| Experiment 8 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 86.39% (Day 15) | Positive ALK expression (ALK+++/++) | ||
| Method Description |
The in vivo efficacy of CDX-0125-TEI was evaluated in female CB17 SCID mice bearing COG-N-424x (ALK wild-type). Upon enrollment, mice (n = 10 per group) were intraperitoneally injected with 15 mg/kg CDX-0125-TE on day 0 of enrollment and on day 7.
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| In Vivo Model | Neuroblastoma PDX model (PDX: COG-N-424x) | ||||
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 11.43% (Day 11) | Positive ALK expression (ALK+++/++) | ||
| Method Description |
The in vivo efficacy of CDX-0125-TEI was evaluated in female CB17 SCID mice bearing NBL-S cells (ALK wild-type). Upon enrollment, mice (n = 10 per group) were intraperitoneally injected with 15 mg/kg CDX-0125-TE on day 0 of enrollment and on day 7.
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| In Vivo Model | NBL-S CDX model | ||||
| In Vitro Model | Neuroblastoma | NBL-S cells | CVCL_2136 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 89.71% (Day 11) | Positive ALK expression (ALK+++/++) | ||
| Method Description |
The in vivo efficacy of CDX-0125-TEI was evaluated in female CB17 SCID mice bearing NBL-S cells (ALK wild-type). Upon enrollment, mice (n = 10 per group) were intraperitoneally injected with 15 mg/kg CDX-0125-TE on day 0 of enrollment and on day 7.
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| In Vivo Model | NBL-S CDX model | ||||
| In Vitro Model | Neuroblastoma | NBL-S cells | CVCL_2136 | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
4.70 pM
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Positive ALK expression (ALK+++/++) | ||
| Method Description |
Cells were seeded at 2000 cells per well in black 96-well proliferation plates and dosed with a titration of conjugates for 3 to 5 days, until control untreated cells reached 80 to 90% confluence.
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| In Vitro Model | Neuroblastoma | IMR-32 cells | CVCL_0346 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
5.80 pM
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Positive ALK expression (ALK+++/++) | ||
| Method Description |
Cells were seeded at 2000 cells per well in black 96-well proliferation plates and dosed with a titration of conjugates for 3 to 5 days, until control untreated cells reached 80 to 90% confluence.
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| In Vitro Model | Buccal mucosa squamous cell carcinoma | NB-1 cells | CVCL_GZ01 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
21.70 pM
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Moderate ALK expression (ALK++) | ||
| Method Description |
Cells were seeded at 2000 cells per well in black 96-well proliferation plates and dosed with a titration of conjugates for 3 to 5 days, until control untreated cells reached 80 to 90% confluence.
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| In Vitro Model | Neuroblastoma | SK-N-SH cells | CVCL_0531 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 1000 pM | Negative ALK expression (ALK-) | ||
| Method Description |
Cells were seeded at 2000 cells per well in black 96-well proliferation plates and dosed with a titration of conjugates for 3 to 5 days, until control untreated cells reached 80 to 90% confluence.
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| In Vitro Model | Neuroblastoma | SK-N-AS cells | CVCL_1700 | ||
References
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