Payload Information
General Information of This Payload
| Payload ID | PAY0LFMHT |
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| Name | PBA-Cur |
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| Synonyms |
PBA-curcumin
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| Target | Programmed cell death 1 ligand 1 (CD274) | |||||
| Isosmiles | COC1=C(C=CC(/C=C/C2=CC(/C=C/C3=CC=C(C(OC)=C3)O)=OB(O)(C4=CC=C(COC(OC5=CC=C(C=C5)[N+]([O-])=O)=O)C=C4)O2)=C1)O |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
Anti-PDL1-PBA-Cur [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.5196 ug/mL
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| Method Description |
The in vitro cytotoxicity of anti-PD-L1-PBA-Cur on colon cancer cells was investigated. The HCT116 cells were seeded at a density of 5 × 103 cells/well in a 96-well plate to attach overnight. After co-incubation with 48 h, the cell's viability was investigated using the MTT assay. The cell morphology was further observed using the microscopy.
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| In Vitro Model | Colon carcinoma | HCT116 cells | CVCL_0291 | ||
References