Target Information
General Information of This Target
| Target ID | PTAR0FHGIS |
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| Target Name | Programmed cell death 1 ligand 1 (CD274) |
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| Gene Name | CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1 |
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| Synonym | B7H1; PDCD1L1; PDCD1LG1; PDL1 |
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| Sequence |
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET Click to Show/Hide
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| Family | Immunoglobulin superfamily, BTN/MOG family |
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| Function |
FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.
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