Payload Information

General Information of This Payload

Payload ID	PAY0IVXDT
Name	WO2025015586A1, ADC22, Payload
Synonyms	WO2025015586A1, ADC22, Payload Click to Show/Hide
Target	DNA topoisomerase I (TOP1)		Target Info
Structure
Structure	3D MOL	2D MOL

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

wO2023232144A1ADC26 [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Max Tumor Growth lnhibition value (TGl) (d)	> 50%	Positive TLR expression (TLR+++/++)
Method Description	ADC26 was tested in mouse M38 CRC model in C57BL/6 mice, 3 mg/kg, QWx3, IV
In Vivo Model	Mouse MC38 CRC Model in C57BL/6 Mice

References

Ref 1	Drug conjugates of imidazoquinoline amine derivatives, compositions and methods thereof