Payload Information
General Information of This Payload
| Payload ID | PAY0IJNBT |
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|---|---|---|---|---|---|---|
| Name | I034 |
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| Target | IKZF1/3 | |||||
| Structure |
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| Isosmiles | OC1(CCC1)C(N2CCC(N3C=C(CC4=CC=C5N(C(C6=CC=CC4=C56)=O)C7CCC(NC7=O)=O)C=N3)CC2)=O |
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The activity data of This Payload
| Standard Type | Value | Units | Cell line | Disease Model | Cell line ID | Reference |
|---|---|---|---|---|---|---|
| Half Maximal Inhibitory Concentration (IC50) | 0.007 | nM |
NCI-H929 cells
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Multiple myeloma
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| Half Maximal Degradation Concentration (DC50) | 0.024 | nM |
NCI-H929 cells
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Multiple myeloma
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| Half Maximal Degradation Concentration (DC50) | <0.05 | nM |
PBMC cells
|
Normal
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| Half Maximal Degradation Concentration (DC50) | 0.092 | nM |
MM.1S cells
|
Multiple myeloma
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Each Antibody-drug Conjugate Related to This Payload