Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ID: DRG0QAQVX)
| ADC Name |
Dara-VA-I034 (4)
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| Synonyms |
Dara-VA-I034 (4)
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
~4
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| Structure |
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| Antibody Name |
Daratumumab
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Antibody Info | ||||
| Antigen Name |
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
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Antigen Info | ||||
| Payload Name |
I034
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Payload Info | ||||
| Payload Target |
IKZF1/3
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Target Info | ||||
| Linker Name |
MC-VA
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.0183 nM
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| In Vitro Model | Plasma cell myeloma | NCI-H929 cells | CVCL_1600 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.0776 nM
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| In Vitro Model | Plasma cell myeloma, Multiple myeloma | MM.1S cells | CVCL_8792 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 50 nM | |||
| In Vitro Model | Normal | PBMC cells | CVCL_0140 | ||
References