Payload Information

General Information of This Payload

Payload ID	PAY0IJDKT
Name	Tubulysin 7
Synonyms	Tubulysin G; 799822-08-5; EX-A5466G; HY-N7050; AKOS040740945; CS-0101873 Click to Show/Hide
Target(s)	Microtubule (MT)			Target Info
Structure
Structure	3D MOL		2D MOL
Formula	C43H63N5O10S
Isosmiles	CC[C@H](C)[C@@H](C(=O)N(COC(=O)C=C(C)C)[C@H](C[C@H](C1=NC(=CS1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C[C@H](C)C(=O)O)OC(=O)C)C(C)C)NC(=O)[C@H]3CCCCN3C
PubChem CID	11170391
InChI	InChI=1S/C43H63N5O10S/c1-10-27(6)38(46-40(53)34-13-11-12-18-47(34)9)42(54)48(24-57-37(51)19-25(2)3)35(26(4)5)22-36(58-29(8)49)41-45-33(23-59-41)39(52)44-31(20-28(7)43(55)56)21-30-14-16-32(50)17-15-30/h14-17,19,23,26-28,31,34-36,38,50H,10-13,18,20-22,24H2,1-9H3,(H,44,52)(H,46,53)(H,55,56)/t27-,28-,31+,34+,35+,36+,38-/m0/s1
InChIKey	QRLSJCMHFBSSJW-OEJISELMSA-N
IUPAC Name	(2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbut-2-enoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoic acid
Pharmaceutical Properties	Molecule Weight	842.1	Polar area	233
	Complexity	1450	xlogp Value	4.8
	Heavy Count	59	Rot Bonds	23
	Hbond acc	13	Hbond Donor	4

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

Alpha-CD30-7 [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 93.10% (Day 28)	Positive CD30 expression (CD30+++/++)
Method Description	Alpha-CD30-7 (0.3 m ug/kg, every seven days x3) induces efficient tumor cell killing in cell line-derived models of CD30+, MDR-L540cy HL cells with CD30 expression with high expression.
In Vivo Model	L540cy CDX model
In Vitro Model	Hodgkin's disease	L540cy cells		Homo sapiens
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 100.00% (Day 16)	Positive CD30 expression (CD30+++/++)
Method Description	Alpha-CD30-7 (1 m ug/kg, every seven days x3) induces efficient tumor cell killing in cell line-derived models of CD30+, MDR+ DEL/BVR ALCL cells with CD30 expression with high expression.
In Vivo Model	DEL/BVR CDX model
In Vitro Model	Anaplastic large cell lymphoma	DEL/BVR cells		CVCL_1170

References

Ref 1	Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR(+) and Heterogeneous Tumor Models. Mol Cancer Ther. 2018 Aug;17(8):1752-1760. doi: 10.1158/1535-7163.MCT-18-0073. Epub 2018 Jun 4.