Payload Information

General Information of This Payload

Payload ID	PAY0HWSWJ
Name	Pseudomonas exotoxin PE24 mut
Synonyms	Pseudomonas exotoxin PE24mut Click to Show/Hide
Target(s)	Eukaryotic elongation factor 2 (EEF2)	Target Info

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

hD7-1 (VL-VH)-PE24mut [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	39.00 pM	Positive PSMA expression (PSMA+++/++)
Method Description	The immunotoxins hD7-1 (VL-VH)-PE24mut was tested for specific cytotoxic activity against PSMA-positive LNCaP and C4-2 cells.
In Vitro Model	Lymph node metastasis of prostate carcinoma	LNCaP C4-2 cells		CVCL_4782
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.18 nM	Positive PSMA expression (PSMA+++/++)
Method Description	The immunotoxins hD7-1 (VL-VH)-PE24mut was tested for specific cytotoxic activity against PSMA-positive LNCaP and C4-2 cells.
In Vitro Model	Prostate carcinoma	LNCaP cells		CVCL_0395

References

Ref 1	In Vitro Evaluation of Humanized/De-immunized Anti-PSMA Immunotoxins for the Treatment of Prostate Cancer. Anticancer Res. 2018 Jan;38(1):61-69. doi: 10.21873/anticanres.12192.

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