Payload Information
General Information of This Payload
| Payload ID | PAY0HDAPU |
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|---|---|---|---|---|---|---|
| Name | (R)B19 |
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| Synonyms |
(R)B19
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| Target | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) | |||||
| Structure |
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| Formula | C29H34ClN5O5 |
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| Isosmiles | O=C1C(C=CC(CNC(NC(C=C2)=CC(Cl)=C2CCCO[C@H]3CNCCC3)=O)=C4)=C4CN1C(CCC5=O)C(N5)=O |
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| InChI |
InChI=1S/C29H34ClN5O5/c30-24-14-21(7-6-19(24)3-2-12-40-22-4-1-11-31-16-22)33-29(39)32-15-18-5-8-23-20(13-18)17-35(28(23)38)25-9-10-26(36)34-27(25)37/h5-8,13-14,22,25,31H,1-4,9-12,15-17H2,(H2,32,33,39)(H,34,36,37)/t22-,25?/m1/s1
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| InChIKey |
AUCAGMGHZBLJIS-UFUCKMQHSA-N
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| Pharmaceutical Properties | Molecule Weight |
568.074 |
Polar area |
128.87 |
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Complexity |
1246.794577 |
xlogp Value |
3.1239 |
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Heavy Count |
40 |
Rot Bonds |
9 |
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Hbond acc |
6 |
Hbond Donor |
4 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024222841A1 ADC43 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 15 pM | High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of ADC to SK-BR-3 cells
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
WO2024222841A1 ADC43-4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
15-25 pM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of ADC to SK-BR-3 cells
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||