Payload Information
General Information of This Payload
Payload ID | PAY0FLWQH |
|||||
---|---|---|---|---|---|---|
Name | PBD dimer SG3315 |
|||||
Synonyms |
PBD dimer SG3315
Click to Show/Hide
|
|||||
Target(s) | Human Deoxyribonucleic acid (hDNA) |
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
HD12-SG3315 [Investigative]
Revealed Based on the Cell Line Data
Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Maximum inhibition efficiency (MIE) |
41.50 pM
|
Moderate MET expression (MET++; IHC H-score=180) | ||
Method Description |
Cell viability was determined by measuring the luminescence after adding the CellTiter-Glo 2.0 reagent. Cancer cells were seeded overnight in growth media and incubated at 37°C, 5% CO2,and 95% humidity. starting with concentrations of 100 nM for ADCs for free drug. Cells were exposed to test articlesfor 5 days.
|
||||
In Vitro Model | Lung adenocarcinoma | NCI-H1373 cells | CVCL_1465 | ||
Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Maximum inhibition efficiency (MIE) |
46.00 pM
|
Moderate MET expression (MET++; IHC H-score=130) | ||
Method Description |
Cell viability was determined by measuring the luminescence after adding the CellTiter-Glo 2.0 reagent. Cancer cells were seeded overnight in growth media and incubated at 37°C, 5% CO2,and 95% humidity. starting with concentrations of 100 nM for ADCs for free drug. Cells were exposed to test articlesfor 5 days.
|
||||
In Vitro Model | Lung adenocarcinoma | NCI-H1975 cells | CVCL_1511 | ||
Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
19.70 pM
|
Moderate MET expression (MET++; IHC H-score=180) | ||
Method Description |
Cell viability was determined by measuring the luminescence after adding the CellTiter-Glo 2.0 reagent. Cancer cells were seeded overnight in growth media and incubated at 37°C, 5% CO2,and 95% humidity. starting with concentrations of 100 nM for ADCs for free drug. Cells were exposed to test articlesfor 5 days.
|
||||
In Vitro Model | Lung adenocarcinoma | NCI-H1373 cells | CVCL_1465 | ||
Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.15 nM
|
Moderate MET expression (MET++; IHC H-score=130) | ||
Method Description |
Cell viability was determined by measuring the luminescence after adding the CellTiter-Glo 2.0 reagent. Cancer cells were seeded overnight in growth media and incubated at 37°C, 5% CO2,and 95% humidity. starting with concentrations of 100 nM for ADCs for free drug. Cells were exposed to test articlesfor 5 days.
|
||||
In Vitro Model | Lung adenocarcinoma | NCI-H1975 cells | CVCL_1511 |
References
If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.