Payload Information

General Information of This Payload

Payload ID	PAY0EJXWD
Name	Shiga toxin B subunit (StxB)
Synonyms	Shiga toxin B subuni (StxB) Click to Show/Hide
Target(s)	Ribosome (RB)	Target Info

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

1B-3R ADC [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 57.11% (Day 12)
Method Description	The inhibitory activity of 1B-3R conjugate against cancer cell growth was evaluated in various human cancer cell lines in vivo.
In Vivo Model	Colorectal cancer CDX model
In Vitro Model	Colorectal cancer	Colorectal cancer cells	Homo sapiens

References

Ref 1	Repurposing the Pentameric B-Subunit of Shiga Toxin for Gb3-Targeted Immunotherapy of Colorectal Cancer by Rhamnose Conjugation. J Pharm Sci. 2022 Oct;111(10):2719-2729.

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