Payload Information
General Information of This Payload
| Payload ID | PAY0EESTN |
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|---|---|---|---|---|---|---|
| Name | FD2 |
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| Synonyms |
FD2
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| Target | DNA topoisomerase I (TOP1) | |||||
| Structure |
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| Formula | C25H25FN4O6 |
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| Isosmiles | CC[C@]1(O)C(C=C2C3=NC4=CC(F)=C(C)C=C4C(CNC(NCCO)=O)=C3CN52)=C(COC1=O)C5=O |
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| PubChem CID | ||||||
| InChI |
InChI=1S/C25H25FN4O6/c1-3-25(35)17-7-20-21-15(10-30(20)22(32)16(17)11-36-23(25)33)14(9-28-24(34)27-4-5-31)13-6-12(2)18(26)8-19(13)29-21/h6-8,31,35H,3-5,9-11H2,1-2H3,(H2,27,28,34)/t25-/m0/s1
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| InChIKey |
KRSPCZFYSZZPMK-VWLOTQADSA-N
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| Pharmaceutical Properties | Molecule Weight |
496.495 |
Polar area |
142.78 |
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Complexity |
1454.107326 |
xlogp Value |
1.31862 |
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Heavy Count |
36 |
Rot Bonds |
5 |
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Hbond acc |
8 |
Hbond Donor |
4 |
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The activity data of This Payload
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
38354417 T-DL3 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.007 nM
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High HER2 expression (HER2 +++) | ||
| Method Description |
A total of 30,000 SK-BR-3 (HER2-high) cells were seeded either as monocultures or cocultures in TC-treated 48-well microtiter plates (Greiner Bio-One, catalog no. 667180) and treated with 1.0 or 0.1 nmol/L ADCs diluted in growth medium.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 30 nM | Negative HER2 expression (HER2-) | ||
| Method Description |
A total of 10,000 MDA-MB-468 (HER2-negative) cells were seeded either as monocultures or cocultures in TC-treated 48-well microtiter plates (Greiner Bio-One, catalog no. 667180) and treated with 1.0 or 0.1 nmol/L ADCs diluted in growth medium.
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
References