Payload Information
General Information of This Payload
| Payload ID | PAY0DLBJA |
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|---|---|---|---|---|---|---|
| Name | TLR7/8 agonist 20h |
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| Synonyms |
TLR7/8 agonist 20h
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| Target | Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) | |||||
| Formula | C20H23N5S |
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| Isosmiles | CCCCC(N1CC2=CC=C(CN)C=C2)=NC3=C1C(SC=C4)=C4N=C3N |
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| PubChem CID | ||||||
| InChI |
InChI=1S/C20H23N5S/c1-2-3-4-16-24-17-18(19-15(9-10-26-19)23-20(17)22)25(16)12-14-7-5-13(11-21)6-8-14/h5-10H,2-4,11-12,21H2,1H3,(H2,22,23)
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| InChIKey |
PKTBLMABRWRYOS-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
365.506 |
Polar area |
82.75 |
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Complexity |
1021.465269 |
xlogp Value |
4.0778 |
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Heavy Count |
26 |
Rot Bonds |
6 |
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Hbond acc |
6 |
Hbond Donor |
2 |
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The activity data of This Payload
| Standard Type | Value | Units | Cell line | Disease Model | Cell line ID | Reference |
|---|---|---|---|---|---|---|
| Half Maximal Effective Concentration (EC50) | 410 | nM |
Cancer cells
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Multiple myeloma, Plasma cell myeloma
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Undisclosed | |
| Half Maximal Effective Concentration (EC50) | 7.6 | nM |
Cancer cells
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Multiple myeloma, Plasma cell myeloma
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Undisclosed |
Each Antibody-drug Conjugate Related to This Payload