Payload Information
General Information of This Payload
| Payload ID | PAY0DKNWM |
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| Name | ADC 3-12 payload |
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| Synonyms |
ADC3-12 payload
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| Target(s) | DNA topoisomerase 1 (TOP1) | |||||
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
ADC3-12 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Maximum inhibition efficiency (MIE) |
75.60%
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Positive HER2 expression (HER2 +++/++) | ||
| Method Description |
Seeding cells (HCC1569) into 96-well plate, at 2E3 cell per well (80 uL/well). Overnight incubation.
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| In Vitro Model | Breast ductal carcinoma | HCC1569 cells | CVCL_1255 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.53 nM
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Positive HER2 expression (HER2 +++/++) | ||
| Method Description |
Seeding cells (HCC1569) into 96-well plate, at 2E3 cell per well (80 uL/well). Overnight incubation.
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| In Vitro Model | Breast ductal carcinoma | HCC1569 cells | CVCL_1255 | ||
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