Payload Information
General Information of This Payload
| Payload ID | PAY0COVTH |
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|---|---|---|---|---|---|---|
| Name | Imiquimod |
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| Synonyms |
imiquimod
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|
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| Target | Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) | |||||
| Formula | C22H25N5 |
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| Isosmiles | NCC1=CC=C(CN(C(CCCC)=N2)C3=C2C(N)=NC4=CC=CC=C43)C=C1 |
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| PubChem CID | ||||||
| InChI |
InChI=1S/C22H25N5/c1-2-3-8-19-26-20-21(17-6-4-5-7-18(17)25-22(20)24)27(19)14-16-11-9-15(13-23)10-12-16/h4-7,9-12H,2-3,8,13-14,23H2,1H3,(H2,24,25)
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| InChIKey |
SDSKFWHQCNBICO-UHFFFAOYSA-N
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| Pharmaceutical Properties | Molecule Weight |
359.477 |
Polar area |
82.75 |
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Complexity |
1060.790051 |
xlogp Value |
4.0163 |
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Heavy Count |
27 |
Rot Bonds |
6 |
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Hbond acc |
5 |
Hbond Donor |
2 |
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The activity data of This Payload
| Standard Type | Value | Units | Cell line | Disease Model | Cell line ID | Reference |
|---|---|---|---|---|---|---|
| Half Maximal Effective Concentration (EC50) | 0.00402 | ug.mL-1 |
HEK293 cells
|
Normal
|
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| Half Maximal Effective Concentration (EC50) | 0.0675 | ug.mL-1 |
HEK293 cells
|
Normal
|
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| Half Maximal Effective Concentration (EC50) | 1 | nM | Undisclosed | Undisclosed | Undisclosed | |
| Half Maximal Effective Concentration (EC50) | 1 | nM | Undisclosed | Undisclosed | Undisclosed | |
| Half Maximal Effective Concentration (EC50) | 130 | nM |
Cancer cells
|
Multiple myeloma, Plasma cell myeloma
|
Undisclosed | |
| Half Maximal Effective Concentration (EC50) | 20 | nM |
HEK cells
|
Endocervical adenocarcinoma
|
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| Half Maximal Effective Concentration (EC50) | 20 | nM | Undisclosed | Undisclosed | Undisclosed | |
| Half Maximal Effective Concentration (EC50) | 217 | nM | Undisclosed | Undisclosed | Undisclosed | |
| Half Maximal Effective Concentration (EC50) | 217 | nM | Undisclosed | Undisclosed | Undisclosed | |
| Half Maximal Effective Concentration (EC50) | 528 | nM |
HEK293 cells
|
Normal
|
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| Half Maximal Effective Concentration (EC50) | 55 | nM |
HEK293 cells
|
Normal
|
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| Half Maximal Effective Concentration (EC50) | 8 | nM |
Cancer cells
|
Multiple myeloma, Plasma cell myeloma
|
Undisclosed | |
| Half Maximal Effective Concentration (EC50) | 800 | nM |
HEK cells
|
Endocervical adenocarcinoma
|
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| Half Maximal Inhibitory Concentration (IC50) | 24.5 | uM |
Human HEK 293 cells
|
Normal
|
[1] | |
| Half Maximal Inhibitory Concentration (IC50) | 24.5 | uM |
Human HEK 293 cells
|
Normal
|
[1] | |
| Half Maximal Inhibitory Concentration (IC50) | 6.7 | uM |
HEK 293 cells
|
Normal
|
[1] | |
| Half Maximal Inhibitory Concentration (IC50) | 6.7 | uM |
HEK 293 cells
|
Normal
|
[1] |
Each Antibody-drug Conjugate Related to This Payload
References