Payload Information
General Information of This Payload
| Payload ID | PAY0BOXTP |
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|---|---|---|---|---|---|---|
| Name | NMT inhibitor 26 |
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| Synonyms |
NMT inhibitor 26; ZA202500415A-ADC-Example-5-payload
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| Target | N-Myristoyltransferase (NMT) | |||||
| Structure |
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| Formula | C23H29ClN8O |
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| Isosmiles | CC(C)(NC(C1CN(C2=C(Cl)C=NC(N3CCNC[C@@H]3C)=N2)C1)=O)C4=CN=C5C=CC=CN54 |
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| PubChem CID | ||||||
| InChI |
InChI=1S/C23H29ClN8O/c1-15-10-25-7-9-31(15)22-27-11-17(24)20(28-22)30-13-16(14-30)21(33)29-23(2,3)18-12-26-19-6-4-5-8-32(18)19/h4-6,8,11-12,15-16,25H,7,9-10,13-14H2,1-3H3,(H,29,33)/t15-/m0/s1
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| InChIKey |
QWUWWVNMDGCKNW-HNNXBMFYSA-N
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| Pharmaceutical Properties | Molecule Weight |
468.993 |
Polar area |
90.69 |
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Complexity |
1133.809634 |
xlogp Value |
2.0635 |
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Heavy Count |
33 |
Rot Bonds |
5 |
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Hbond acc |
8 |
Hbond Donor |
2 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
ZA202500415A-ADC Example 5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.18 uM
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| Method Description |
ZR-75-30 Cells were plated at set initial densities in 96 well flat bottom plates in the appropriate growth media. 24 hours later, dosing solutions were added at serial dilutions of each test compound spanning a concentration range of either 50 nM to 0.005 nM for the various ADCs. Cell proliferation was measured after 144 hours exposure, by CellTiter-Glo 2.0 Solution Cell Viability Assay.
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| In Vitro Model | Breast carcinoma | ZR-75-30 cells | CVCL_1661 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
2.712 uM
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Positive her2 expression (her2+++/++) | ||
| Method Description |
BT-474 cells were plated at set initial densities in 96 well flat bottom plates in the appropriate growth media. 24 hours later, dosing solutions were added at serial dilutions of each test compound spanning a concentration range of either 50 nM to 0.005 nM for the various ADCs. Cell proliferation was measured after 144 hours exposure, by CellTiter-Glo 2.0 Solution Cell Viability Assay.
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| In Vitro Model | Invasive breast carcinoma | BT-474 cells | CVCL_0179 | ||