Target Information

General Information of This Target
Target ID
PATR0NRQPL
Target Name
Glycylpeptide N-tetradecanoyltransferase 1 (NMT1)
Gene Name
NMT1
Gene ID
4836
Synonym
Myristoyl-CoA:protein N-myristoyltransferase 1; Peptide N-myristoyltransferase 1; Protein-lysine myristoyltransferase NMT1
Sequence
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKK
QKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFW
DTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENY
VEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEK
KMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQF
HLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAY
SFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYN
WKCPSMGAEKVGLVLQ

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Family
the NMT family
Function
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle.

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Uniprot Entry
NMT1_HUMAN
HGNC ID
HGNC:7857
KEGG ID
hsa:4836
Full List of The ADC Related to This Target
Investigative
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
 ADC Info 
MYX2449
Trastuzumab
ERBB2
N-Myristolytransferase inhibitor (NMTi)
Undisclosed
 [1]
References
Ref 1 N-Myristolytransferase (NMT) inhibitors as novel potent payloads for antibody drug conjugates. Cancer Res (2023) 83 (7_Supplement): 2635.

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