Linker Information
General Information of This Linker
| Linker ID |
LIN0WVXNJ
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| Linker Name |
DBCO-PEG4-Mc-Gly-Gly-Phe-Gly
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C45H54N6O12
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| Isosmiles |
O=C(N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3)CCC(NCCOCCOCCOCCOCCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(O)=O)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C45H54N6O12/c52-39(16-17-43(56)51-32-36-12-5-4-10-34(36)14-15-35-11-6-7-13-38(35)51)46-19-21-61-23-25-63-27-26-62-24-22-60-20-18-40(53)47-29-41(54)48-30-42(55)50-37(45(59)49-31-44(57)58)28-33-8-2-1-3-9-33/h1-13,37H,16-32H2,(H,46,52)(H,47,53)(H,48,54)(H,49,59)(H,50,55)(H,57,58)/t37-/m0/s1
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| InChIKey |
NLAQYNJWFVJVOU-QNGWXLTQSA-N
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| Pharmaceutical Properties |
Molecule Weight
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870.957
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Polar area
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240.03
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Complexity
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1983.366
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xlogp Value
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0.4466
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Heavy Count
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63
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Rot Bonds
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28
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Hbond acc
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11
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
Anbenitamab repodatecan [Phase 3]
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Objective Response Rate (ORR) |
50%
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| Patients Enrolled |
Eligible patients require HER2-positive (IHC≥1+) advanced solid tumors (ECOG 0-1, life expectancy ≥12 weeks), measurable disease (RECIST 1.1), adequate organ function, and no recent transfusions/G-CSF. Key exclusions include untreated CNS metastases, LVEF<50%, or pregnancy. Contraception is mandated for 180 days post-treatment.
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| Related Clinical Trial | |||||
| NCT Number | NCT05494918 | Clinical Status | PHASE1 | ||
| Clinical Description |
A Phase I, Multi-center, Open-label, Dose Escalation, First-In-Human Study to Assess the Safety, Tolerability and Pharmacokinetics of JSKN003 in Subjects With Advanced or Metastatic Solid Malignant Tumors
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| Primary Endpoint |
Primary objectives include determining MTD/RP2D, assessing DLTs within 21 days post-first dose, and monitoring safety (TEAEs/TRAEs/SAEs) up to 1 year post-treatment.
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| Other Endpoint |
Secondary endpoints cover PK profiling (Cmax/Tmax/AUC/t½ of JSKN003 up to Day 90), efficacy measures (ORR/TTR/DoR/PFS per RECIST v1.1 over 1 year), and immunogenicity (anti-drug antibodies).
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| Experiment 2 Reporting the Activity Date of This ADC | [2] | ||||
| Efficacy Data | Objective Response Rate (ORR) |
51.40%
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| Patients Enrolled |
Eligible patients must have advanced/metastatic solid tumors (ECOG 0-1, life expectancy ≥12 weeks), measurable disease (RECIST 1.1), adequate organ function, and provide tumor samples. Fertile subjects require contraception until 180 days post-treatment.
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| Administration Dosage |
JSKN003 should be administered intravenously on the first day of each 3-week cycle.
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| Related Clinical Trial | |||||
| NCT Number | NCT05744427 | Clinical Status | PHASE1|||PHASE2 | ||
| Clinical Description |
Phase I/II Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics/Pharmacodynamics, and Antitumor Activity of JSKN003 in Chinese Subjects With Advanced Solid Tumors
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| Primary Endpoint |
Primary endpoints include DLT assessment (dose escalation phase), MTD/RP2D determination (BOIN design), safety monitoring (TEAEs/SAEs per CTCAE v5.0 over 2 years), and ORR evaluation (RECIST v1.1 in phase 2).
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| Other Endpoint |
Secondary measures comprise efficacy (CBR, PFS, DOR), PK parameters (Cmax/Tmax/AUC/t½ of JSKN003), and immunogenicity (anti-drug antibodies) throughout the 2-year study duration.
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| Experiment 3 Reporting the Activity Date of This ADC | [3] | ||||
| Efficacy Data | Disease control rate (DCR) |
75%
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| Patients Enrolled |
Eligible patients must have HER2-expressing (IHC≥1+ or NSCLC mutations) advanced solid tumors (ECOG 0-1, life expectancy ≥12 weeks), measurable disease (RECIST 1.1), adequate organ function, and no prior topoisomerase I inhibitor ADCs. Key exclusions include active CNS metastases, uncontrolled comorbidities, unresolved treatment toxicities (>CTCAE v5.0 grade 1), or severe hypersensitivity to HER2 therapies/ADC components.
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| Administration Dosage |
As of August 20, 2024, ten patients had been enrolled (n=4 breast cancer, n=2 NSCLC, n=2 biliary tract cancer, n=1 colorectal cancer, and n=1 salivary gland cancer) (table 1). Patients received JSKN033 at doses of 1.1 mg/kg (n=1), 2.3 mg/kg (n=1), 4.5 mg/kg (n=3), 5.6 mg/kg (n=3), and 6.7 mg/kg (n=2). The most common treatment-related adverse event (TRAE) was mild to moderate injection site reactions (Grade 1-2). No Grade 3 or higher TRAEs or serious adverse events were observed, and no TRAEs led to treatment discontinuation.
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| Related Clinical Trial | |||||
| NCT Number | NCT06226766 | Clinical Status | PHASE1|||PHASE2 | ||
| Clinical Description |
Phase I/II Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of JSKN033 in Patients With Advanced or Metastatic Solid Malignant Tumors
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| Primary Endpoint |
Primary endpoints include safety assessment (TEAEs/TRAEs/SAEs per CTCAE v5.0 over 1 year), RP2D determination, DLT evaluation (first 21 days), and investigator-assessed ORR (RECIST v1.1 criteria within 1 year post-treatment).
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| Other Endpoint |
Secondary endpoints comprise PK analysis (Cmax/Tmax/AUC for JSKN003 components over 1 year), efficacy outcomes (investigator-assessed PFS/DoR/OS per RECIST v1.1 within 1 year), and immunogenicity monitoring.
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| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Disease control rate (DCR) |
90.60%
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| Patients Enrolled |
Eligible patients require HER2-positive (IHC≥1+) advanced solid tumors (ECOG 0-1, life expectancy ≥12 weeks), measurable disease (RECIST 1.1), adequate organ function, and no recent transfusions/G-CSF. Key exclusions include untreated CNS metastases, LVEF<50%, or pregnancy. Contraception is mandated for 180 days post-treatment.
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| Related Clinical Trial | |||||
| NCT Number | NCT05494918 | Clinical Status | PHASE1 | ||
| Clinical Description |
A Phase I, Multi-center, Open-label, Dose Escalation, First-In-Human Study to Assess the Safety, Tolerability and Pharmacokinetics of JSKN003 in Subjects With Advanced or Metastatic Solid Malignant Tumors
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| Primary Endpoint |
Primary objectives include determining MTD/RP2D, assessing DLTs within 21 days post-first dose, and monitoring safety (TEAEs/TRAEs/SAEs) up to 1 year post-treatment.
|
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| Other Endpoint |
Secondary endpoints cover PK profiling (Cmax/Tmax/AUC/t½ of JSKN003 up to Day 90), efficacy measures (ORR/TTR/DoR/PFS per RECIST v1.1 over 1 year), and immunogenicity (anti-drug antibodies).
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| Experiment 5 Reporting the Activity Date of This ADC | [2] | ||||
| Efficacy Data | Disease control rate (DCR) |
91.90%
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| Patients Enrolled |
Eligible patients must have advanced/metastatic solid tumors (ECOG 0-1, life expectancy ≥12 weeks), measurable disease (RECIST 1.1), adequate organ function, and provide tumor samples. Fertile subjects require contraception until 180 days post-treatment.
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| Administration Dosage |
JSKN003 should be administered intravenously on the first day of each 3-week cycle.
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| Related Clinical Trial | |||||
| NCT Number | NCT05744427 | Clinical Status | PHASE1|||PHASE2 | ||
| Clinical Description |
Phase I/II Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics/Pharmacodynamics, and Antitumor Activity of JSKN003 in Chinese Subjects With Advanced Solid Tumors
|
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| Primary Endpoint |
Primary endpoints include DLT assessment (dose escalation phase), MTD/RP2D determination (BOIN design), safety monitoring (TEAEs/SAEs per CTCAE v5.0 over 2 years), and ORR evaluation (RECIST v1.1 in phase 2).
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| Other Endpoint |
Secondary measures comprise efficacy (CBR, PFS, DOR), PK parameters (Cmax/Tmax/AUC/t½ of JSKN003), and immunogenicity (anti-drug antibodies) throughout the 2-year study duration.
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| Experiment 6 Reporting the Activity Date of This ADC | [4] | ||||
| Patients Enrolled |
Eligible patients must have HER2-low (IHC 1+/2+ ISH-) unresectable/metastatic breast cancer (≥18 years, ECOG 0-1) with ≥1 measurable lesion, 1-2 prior chemotherapy lines, adequate organ function, and no prior HER2-targeted ADC therapy or topoisomerase I inhibitor ADCs.
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| Related Clinical Trial | |||||
| NCT Number | NCT06079983 | Clinical Status | PHASE3 | ||
| Clinical Description |
A Phase 3, Multicenter, Randomized, Open-Label, Active-Controlled Trial Of JSKN003 Versus Treatment Of Physician'S Choice For HER2-low, Unresectable and/or Metastatic Breast Cancer Subjects
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| Primary Endpoint |
The primary endpoint is PFS (BICR-assessed per RECIST v1.1) with secondary endpoints including OS, ORR, and DOR (both BICR/investigator-assessed) evaluated at 16/26 months (extended to 60 months for OS).
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| Other Endpoint |
Efficacy assessments focus on time-to-event outcomes (PFS/OS/DOR) and tumor response rates (ORR) using RECIST v1.1 criteria through multiple evaluation timepoints up to 60 months.
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| Experiment 7 Reporting the Activity Date of This ADC | [5] | ||||
| Patients Enrolled |
Key eligibility requires HER2-positive (IHC 3+ or 2+/ISH+) unresectable/metastatic breast cancer patients (≥18y, ECOG 0-1) with prior trastuzumab/taxane exposure, measurable lesions (RECIST 1.1), adequate organ function, and ≥3-month life expectancy.
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| Related Clinical Trial | |||||
| NCT Number | NCT06846437 | Clinical Status | PHASE3 | ||
| Clinical Description |
A Randomized, Controlled, Open-Label, Multicenter, Phase 3 Study to Compare the Efficacy and Safety of JSKN003 Versus Trastuzumab Emtansine (T-DM1) for HER2-Positive, Advanced Breast Cancer Subjects
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| Primary Endpoint |
The primary endpoint is PFS assessed by BIRC per RECIST v1.1 with a 4-year timeframe, alongside comprehensive safety monitoring including TEAEs and SAEs from consent through follow-up.
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| Other Endpoint |
Secondary outcomes include investigator-evaluated PFS, OS, ORR, DCR, DoR over 4 years, plus PK (Cmax/AUC) and immunogenicity (ADA) profiles of JSKN003 across treatment cycles.
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References