Linker Information

General Information of This Linker
Linker ID
LIN0BQCKI
Linker Name
Succinimidyl acetylthiopropionate (SATP)
Linker Type
Flexible reactive (amino) linker
Antibody-Linker Relation
Cleavable
Structure
Formula
C9H11NO4S
Isosmiles
CC(C(=O)C)C(=S)ON1C(=O)CCC1=O
PubChem CID
87149591
InChI
InChI=1S/C9H11NO4S/c1-5(6(2)11)9(15)14-10-7(12)3-4-8(10)13/h5H,3-4H2,1-2H3
InChIKey
OLMXDPGYJUZOLA-UHFFFAOYSA-N
IUPAC Name
O-(2,5-dioxopyrrolidin-1-yl) 2-methyl-3-oxobutanethioate
Pharmaceutical Properties
Molecule Weight
229.26
Polar area
95.8
Complexity
323
xlogp Value
0.3
Heavy Count
15
Rot Bonds
4
Hbond acc
5
Hbond Donor
0
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
Cetuximab-Puromycin [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
37.42 ug/mL
High EGFR expression (EGFR+++)
Method Description
Cells were seeded into 6-well plates, 500,000 cells/well. One day (24 hours) before treatment, MDA-MB-231 cells are being fasted from FBS. Cells are divided into five different doses of conjugate (5 ug/mL; 10 ug/mL; 20 ug/mL; 40 ug/mL; 80 ug/mL) and one untreated group. They were incubated for 48 hours.
In Vitro Model Breast adenocarcinoma MDA-MB-468 cells CVCL_0419
References
Ref 1 Conjugation of Cetuximab - Puromycin and Its Target-Specific Effect on Triple Negative Breast Cancer Cell Lines. Asian Pac J Cancer Prev. 2022 May 1;23(5):1803-1812.

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