Linker Information
General Information of This Linker
| Linker ID |
LIN0AEDTK
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| Linker Name |
Succynimidyloxycarbonyl-alpha-methyl-alpha-(2-pyridyl-dithio) toluene (SMPT)
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| Linker Type |
Rigid dual-reactive (amino/thiol) linker; Thiol-sensitive linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C18H16N2O4S2
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| Isosmiles |
[H]c1nc(SSC([H])(c2c([H])c([H])c(C(=O)ON3C(=O)C([H])([H])C([H])([H])C3=O)c([H])c2[H])C([H])([H])[H])c([H])c([H])c1[H]
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| PubChem CID | ||||||
| InChI |
InChI=1S/C18H16N2O4S2/c1-12(25-26-15-4-2-3-11-19-15)13-5-7-14(8-6-13)18(23)24-20-16(21)9-10-17(20)22/h2-8,11-12H,9-10H2,1H3
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| InChIKey |
GKSPIZSKQWTXQG-UHFFFAOYSA-N
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| IUPAC Name |
(2,5-dioxopyrrolidin-1-yl) 4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoate
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| Pharmaceutical Properties |
Molecule Weight
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388.47
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Polar area
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76.57
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Complexity
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388.055149
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xlogp Value
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3.8039
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Heavy Count
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26
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Rot Bonds
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7
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Hbond acc
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7
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Hbond Donor
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0
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Each Antibody-drug Conjugate Related to This Linker