Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0WCZRN |
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| Antibody Name | hCL1a |
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| Organization | SOTIO BIOTECH A.S |
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| Synonyms |
hCL1a
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized lgG |
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| Antigen Name | Claudin-18.2 (CLDN18.2) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Sequence |
QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYAMHWVRQAPGQNORLEWMGWINTYTGKP
TYAQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCARAVFYGYTMDAWGQGTLVTVS SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQS SGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQY NSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR WQQGNVFSCSVMHEALHNHYTQKSLSLSPGXXisRorK Click to Show/Hide
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| Heavy Chain Varible Domain |
QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYAMHWVRQAPGQRLEWMGWINTYTGKPTY
AQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCARAVFYGYTMDAWGQGTLVTVSS Click to Show/Hide
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| Heavy Chain CDR 1 |
DYAMH
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| Heavy Chain CDR 2 |
WINTYTGKPTYAQKFQG
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| Heavy Chain CDR 3 |
AVFYGYTMDA
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| Light Chain Sequence |
DIQMTQSPSSLSASVGDRVTITCRASEDIYSNLAWYQQKPGKAPKLLIFSVKRLQDGVPS
RFSGSGSGTDFTLTISSLQPEDFATYYCLQGSNFPLTFGQGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC Click to Show/Hide
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| Light Chain Varible Domain |
DIQMTQSPSSLSASVGDRVTITCRASEDIYSNLAWYQQKPGKAPKLLIFSVKRLQDGVPS
RFSGSGSGTDFTLTISSLQPEDFATYYCLQGSNFPLTFGQGTKVEIK Click to Show/Hide
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| Light Chain CDR 1 |
RASEDIYSNLA
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| Light Chain CDR 2 |
SVKRLQD
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| Light Chain CDR 3 |
LQGSNFPLT
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
hCL1a-LC-G2-PNU [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.5976 ug/ml
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High Claudin-18.2 expression (Claudin-18.2 +++) | ||
| Method Description |
A Cell line test on HEK293T
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| In Vitro Model | Normal | HEK293T cells | CVCL_0063 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.5976 ug/ml
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High Claudin-18.2 expression (Claudin-18.2 +++) | ||
| Method Description |
A Cell line test on HEK293T
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| In Vitro Model | Normal | HEK293T cells | CVCL_0063 | ||