Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0TTDLU |
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| Antibody Name | Antibody 12 |
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| Synonyms |
Antibody 12
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized lgG1 |
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| Antigen Name | Syndecan-1 (SDC1) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Varible Domain |
QVQLVQSGAEVKKPGSSVKVSCKASGYTESNYWIEWVRQAPGQGLEWIGEILPGTGRTIY
NEKFKGRVTFTADESTSTAYMELSSLRSEDTAVYYCARRDYYGNFYYAMDYWGQGTLVTV SS Click to Show/Hide
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| Heavy Chain CDR 1 |
NYWIE
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| Heavy Chain CDR 2 |
EILPGTGRTIYNEKFKG
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| Heavy Chain CDR 3 |
RDYYGNFYYAMDY
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| Light Chain Varible Domain |
DIQMTQSPSSLSASVGDRVTITCSASQGINNYLNWYQQKPGKAPKLLIYYTSTLQSGVPS
RESGSGSGTDYTLTISSLQPEDFATYYCQQYSKLPRTFGGGTKVEIK Click to Show/Hide
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| Light Chain CDR 1 |
SASQGINNYLN
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| Light Chain CDR 2 |
YTSTLQS
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| Light Chain CDR 3 |
QQYSKLPRT
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
wO2024181570A1 ADC14 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) | ≈ 85% | Positive CD138 expression (CD138+++/++) | ||
| Method Description |
1x107cells/100 uL, ADC3 at 1 mg/kg, intravenous injection,
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| In Vivo Model | Capan-1 derived Xenograft Model | ||||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
57 ng/mL
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Positive CD138 expression (CD138+++/++) | ||
| Method Description |
1000 cells/well of Capan-1 in 96 well, 37 °C for 5 days.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | Capan-1 cells | CVCL_0237 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
4761 ng/mL
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Negative CD138 expression (CD138-) | ||
| Method Description |
1000 cells/well of Jurkat in 96 well, 37 °C for 5 days.
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| In Vitro Model | T acute lymphoblastic leukemia | Jurkat cells | CVCL_0065 | ||