Antibody Information

General Information of This Antibody
Antibody ID
ANTI0SSDGS
Antibody Name
CDH6 Ab1a
Organization
Eli Lilly and Company, Indianapolis, IN (US)
Synonyms
CDH6 Ab1a
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Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized lgG1
Antigen Name
Cadherin-6 (CDH6)
  Antigen Info 
Click to Show/Hide the Sequence Information of This Antibody
Heavy Chain Sequence
QVQLVQSGAQVKKPGASVKVSCKASGYTFTGYYIHWVRQAPGQGLEWMGWINPNSGGTNY
AQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYFCAREDWDFDYWGQGTLVTVSSASTK
GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLOSSGLYS
LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVF
LFPPKPKDTLMISRTPEVTCVVVSVSHEDPEVKFNWYVDGVEVINAKTKPREEQYNSTYR
VVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKN
QVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN
VFSCSVMHEALHNHYTQKSLSLSPGK
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Heavy Chain Varible Domain
QVQLVQSGAQVKKPGASVKVSCKASGYTFTGYYIHWVRQAPGQGLEWMGWINPNSGGTNY
AQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYFCAREDWDFDYWGQGTLVTVSS
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Heavy Chain CDR 1
KASGYTFTGYYIH
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Heavy Chain CDR 2
WINPNSGGTN
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Heavy Chain CDR 3
AREDWDFDY
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Light Chain Sequence
EIVLTQSPGTLSLSPGERATLSCRTSQSVSSSYLAWYQQKPGQAPRLLIYGASNRATDIP
DRFSGSGSGTDFTLTINRLEPEDFAVYYCQQYGSSPITFGQGTRLEIKRTVAAPSVFIFP
PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTL
TLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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Light Chain Varible Domain
EIVLTQSPGTLSLSPGERATLSCRTSQSVSSSYLAWYQQKPGQAPRLLIYGASNRATDIP
DRFSGSGSGTDFTLTINRLEPEDFAVYYCQQYGSSPITFGQGTRLEIK
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Light Chain CDR 1
KSSQSVLYNSNNKNYLA
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Light Chain CDR 2
YWASTRES
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Light Chain CDR 3
QQFYTTPYS
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
US20250000991A1 Ab1a ADC [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.0587 nM
High Nectin-4 expression (Nectin-4 +++)
Method Description
Ab6 ADC was tested in T24 mScarlet clone 5 nectin-4 negative cells ;and with a DAR of 8
In Vitro Model Bladder carcinoma T24 mScarlet clone 5 nectin-4 negative cells CVCL_0554
References
Ref 1 Nectin-4 antibodies and antibody-drug conjugates