Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0PKPYP |
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| Antibody Name | Anti-TPP-5442 |
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| Organization | REGENERON PHARMACEUTICALS, INC. |
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| Synonyms |
Anti-TPP-5442
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized lgG |
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| Antigen Name | Undisclosed |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
US12144865B2 34t-4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50)Human PBMC |
0.816 nM
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Positive EGFR expression (EGFR+++/++) | ||
| Method Description |
Tables 1b and 1c below set out the IC50 values for representative working examples from this assay
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| In Vitro Model | Lung mucoepidermoid carcinoma | NCI-H292 cells | CVCL_0455 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50)Human PBMC |
0.887 nM
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Positive EGFR expression (EGFR+++/++) | ||
| Method Description |
Tables 1b and 1c below set out the IC50 values for representative working examples from this assay
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| In Vitro Model | Liver and intrahepatic bile duct epithelial neoplasm | SK-HEP-1 cells | CVCL_0525 | ||