Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0JSVTG |
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| Antibody Name | NEC49 (Anti-nectin-4 mAb) |
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| Organization | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. |
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| Synonyms |
NEC49 (Anti-nectin-4 mAb)
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized lgG1 |
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| Antigen Name | Cadherin-6 (CDH6) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Varible Domain |
EVOLLESGGGLVOPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIYSGGSTYYA
DSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRHGGDSGSWSYYYYGMDVWGOGTT VTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPA VLQSSGLYSLSSVVTVPSSSLGTOTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAP ELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR EEOYNSTYRVVSVLTVLHODWLNGKEYKCKVSNKALPAPIEKTISKAKGOPREPQVYTLP PSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGOPENNYKTTPPVLDSDGSFFLYSKLTV DKSRWQQGNVFSCSVMHEALHNHYTOKSLSLSPGK Click to Show/Hide
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| Light Chain Varible Domain |
DIQMTOSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPS
RFSGSGSGTDFTLTISSLOPEDFATYYCOOSYSTPLTFGOGTRLEIKRTVAAPSVFIFPP SDEOLKSVVCLLNNFYPREAKVOWKVDNALOSGNSOESVTEODSKDSTVSLSSTIADVEK HKVYACEVTHOGLSSPVTKSFNRGEC Click to Show/Hide
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
NEC49-9-A [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.0798 nM
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High Nectin-4 expression (Nectin-4 +++) | ||
| Method Description |
Ab4 ADC was tested in T24 mScarlet clone 5 nectin-4 negative cells ;and with a DAR of 8
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| In Vitro Model | Bladder carcinoma | T24 mScarlet clone 5 nectin-4 negative cells | CVCL_0554 | ||