Antibody Information

General Information of This Antibody
Antibody ID
ANTI0HFNLI
Antibody Name
A27
Organization
EXELIXIS, INC.
Synonyms
A27
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Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized lgG
Antigen Name
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
  Antigen Info 
Click to Show/Hide the Sequence Information of This Antibody
Heavy Chain Sequence
EVQLVESGGGLVQPGGSLRLSCAASGFTFKGYYIHWVRQAPGKGLEWVAAIYPYGGSTDY
ADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARVYIYGVFDYWGQGTLVTVSSAS
TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGL
YSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPS
VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNST
YRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELT
KNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ
GNVFSCSVMHEALHNHYTQKSLSLSPGK
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Heavy Chain Varible Domain
EVQLVESGGGLVQPGGSLRLSCAASGFTFKGYYIHWVRQAPGKGLEWVAAIYPYGGSTDY
ADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARVYIYGVFDYWGQGTLVTVSS
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Heavy Chain CDR 1
GFTFKGYYIH
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Heavy Chain CDR 2
AIYPYGGSTDY
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Heavy Chain CDR 3
VYIYGVFDY
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Light Chain Sequence
DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPS
RFSGSRSGTDFTLTISSLQPEDFATYYCQQYYSSPRTFGQGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT
LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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Light Chain Varible Domain
DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPS
RFSGSRSGTDFTLTISSLQPEDFATYYCQQYYSSPRTFGQGTKVEIK
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Light Chain CDR 1
RASQSVSSAVA
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Light Chain CDR 2
SASSLYS
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Light Chain CDR 3
QQYYSSPRT
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
WO2025019787A1 ADC-8 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.318 nM
Positive huROR1 expression (huROR1+++/++)
Method Description
ADC-8 was tested in HEK293-huROR1 cells, starting with a top concentration of 60 nM (4x the final top concentration),each of the samples was serially diluted 5 times (1:4 for ADC-8), 5 days.
In Vitro Model Normal HEK293-huROR1 cells CVCL_0045
References
Ref 1 Tyrosine-protein kinase membrane receptor 1 (ROR1) antibody-drug conjugates and uses thereof