Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0GZVJR |
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| Antibody Name | degly-mAb1 |
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| Organization | REGENERONPHARMACEUTICALS,INC. |
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| Synonyms |
degly-mAb1
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antigen Name | Receptor tyrosine-protein kinase erbB-2 (ERBB2) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Degly-mAb1-1-mc-vc-PAB-MMAE [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.035 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
SKBR3 8000 cell/well were plated at set initial densities in 96 well flat bottom plates in the appropriate growth media. For cell viability curves, serially diluted conjugates or naked payloads were added to the cells at final concentrations ranging from 100 nM to 5 pM and incubated for 3 days. To measure viability, cells were incubated with CCK8 (Dojindo) for the final 2 hours and the absorbance at 450 nm (OD450) was determined on a Victor (Perkin Elmer).
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | Negative HER2 expression (HER2-) | ||
| Method Description |
NCI-H1975 8000 cell/well were plated at set initial densities in 96 well flat bottom plates in the appropriate growth media. For cell viability curves, serially diluted conjugates or naked payloads were added to the cells at final concentrations ranging from 100 nM to 5 pM and incubated for 3 days. To measure viability, cells were incubated with CCK8 (Dojindo) for the final 2 hours and the absorbance at 450 nm (OD450) was determined on a Victor (Perkin Elmer).
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| In Vitro Model | Lung adenocarcinoma | NCI-H1975 cells | CVCL_1511 | ||