Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0GGGQW |
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| Antibody Name | Hu63 |
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| Organization | JIANGSU HENGRUI MEDICINE CO., LTD. |
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| Synonyms |
Hu63
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized lgG |
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| Antigen Name | Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Varible Domain |
EVQLVQSGAEVKKPGASVKVSCKASGYTFTDFYMNWVRQAPGQGLEWMGDIFPKSGNTDY
NRKFKDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARSGYGNYVFDYWGQGTLVTVSSA STKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSG LYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNS TYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQ QGNVFSCSVMHEALHNHYTQKSLSLSPGK Click to Show/Hide
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| Light Chain Varible Domain |
DIQMTQSPSSLSASVGDRVTITCRTSQDINIYLNWYQQKPGKAPKLLIYYRSGLLSGVPS
RFSGSGSGTDFTLTISSLQPEDFATYYCQQGNTLPPTFGGGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC Click to Show/Hide
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Hu63-13-2-A (1) [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
3.933 nM
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High CEACAM5 expression (CEACAM5 +++) | ||
| Method Description |
A Cell line test on MKN45
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| In Vitro Model | Gastric adenocarcinoma | MKN45 cells | CVCL_0434 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
13.08 nM
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Moderate CEACAM5 expression (CEACAM5++) | ||
| Method Description |
A Cell line test on LS174T
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| In Vitro Model | Colon adenocarcinoma | LS174T cells | CVCL_1384 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
87.64 nM
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Negative CEACAM5 expression (CEACAM5-) | ||
| Method Description |
A Cell line test on HCT116
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| In Vitro Model | Colon carcinoma | HCT116 cells | CVCL_0291 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
2.93 nM
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High CEACAM5 expression (CEACAM5 +++) | ||
| Method Description |
A Cell line test on HEK293T
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| In Vitro Model | Normal | HEK293T cells | CVCL_0063 | ||
Hu63-13-2-A (2) [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
34.02 nM
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High CEACAM5 expression (CEACAM5 +++) | ||
| Method Description |
A Cell line test on MKN45
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| In Vitro Model | Gastric adenocarcinoma | MKN45 cells | CVCL_0434 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
34.03 nM
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Moderate CEACAM5 expression (CEACAM5++) | ||
| Method Description |
A Cell line test on LS174T
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| In Vitro Model | Colon adenocarcinoma | LS174T cells | CVCL_1384 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
165.1 nM
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Negative CEACAM5 expression (CEACAM5-) | ||
| Method Description |
A Cell line test on HCT116
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| In Vitro Model | Colon carcinoma | HCT116 cells | CVCL_0291 | ||