General Information of This Antibody
Antibody ID
ANI0ZADON
Antibody Name
Anti-5T4 scFv-Fc antibody
Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized IgG1-kappa/(scFv-Fc-kappa)
Antigen Name
Trophoblast glycoprotein (TPBG)
 Antigen Info 
The Activity Data of This Antibody
Antibody Activity Information 1 [1]
Dissociation Constant (Kd)
<30
pM
Antibody Function Confirm the effect of the drug conjugation with the anti-5T4 Ab and ASN-004 on binding activity to target.
Antibody Antigen Binding Assay Binding kinetics and affinity to human 5T4 extracellular domain antigen protein were determined by surface plasmon resonance (SPR, BIAcore).
Each Antibody-drug Conjugate Related to This Antibody
References
Ref 1 ASN004, A 5T4-targeting scFv-Fc Antibody-Drug Conjugate with High Drug-to-Antibody Ratio, Induces Complete and Durable Tumor Regressions in Preclinical Models. Mol Cancer Ther. 2021 Aug;20(8):1327-1337.