Antibody Information
General Information of This Antibody
| Antibody ID | ANI0UIWOS |
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| Antibody Name | h046-H10/L6 |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized IgG1-kappa |
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| Antigen Name | G-protein coupled receptor 20 (GPR20) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
WO2018135501A1 ADC-12 [Investigative]
Discovered Using Patient-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≓ 66.70% (Day 46) | Positive GPR20 expression (GPR20+++/++) | ||
| Method Description |
To establish gastrointestinal stromal tumor model, 5 x 106 cells were implanted into the right flank of athymic nu/nu female donor mice. When tumors reached ~100 mm3 mice were randomly allocated to treatment groups. The dose of ADC was 1 mg/kg, i.v.*1.
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| In Vivo Model | Gastrointestinal stromal tumor (GIST) PDX model (PDX: GIST-T1/GPR20) | ||||
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