Antibody Information

General Information of This Antibody

Antibody ID	ANI0UBEYU
Antibody Name	Anti-MET mAb
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	Hepatocyte growth factor receptor (MET)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

Anti-c-Met IgG-OXA [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 83.40% (Day 28)	Positive MET expression (MET+++/++)
Method Description	The mice were randomly assigned to groups: those treated with oxaliplatin , anti-c-Met IgG-OXA (10 mg/kg), and vehicle 5% sterile glucose solution. Different drugs were injected intravenously.
In Vivo Model	HepG2 CDX model
In Vitro Model	Hepatoblastoma	Hep-G2 cells		CVCL_0027

References

Ref 1	High-Affinity Human Anti-c-Met IgG Conjugated to Oxaliplatin as Targeted Chemotherapy for Hepatocellular Carcinoma. Front Oncol. 2019 Aug 2;9:717. doi: 10.3389/fonc.2019.00717. eCollection 2019.

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.