Antibody Information
General Information of This Antibody
| Antibody ID | ANI0THIPX |
|||||
|---|---|---|---|---|---|---|
| Antibody Name | SHR-A1403 mAb |
|||||
| Antibody Type | Monoclonal antibody (mAb) |
|||||
| Antibody Subtype | Humanized IgG2-kappa |
|||||
| Antigen Name | Hepatocyte growth factor receptor (MET) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Sequence |
QVQLVESGGGVVQPGRSLRLSCAASGFSLSNYGVHWVRQAPGKGLEWLAVIWSGGSTNYA
AAFVSRLTISKDNSKNTVYLQMNSLRAEDTAVYYCARNHDNPYNYAMDYWGQGTTVTVSS ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSS GLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVF LFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFR VVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKN QVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK Click to Show/Hide
|
|||||
| Light Chain Sequence |
DIVLTQSPDSLAVSLGERATINCRADKSVSTSTYNYLHWYQQKPGQPPKLLIYLASNLAS
GVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSRDLPPTFGQGTKLEIKRTVAAPSVF IFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC Click to Show/Hide
|
|||||
The Activity Data of This Antibody
| Antibody Activity Information 1 | [1] | |||||
|
Dissociation Constant (Kd)
|
15.8
|
nM
|
||||
|---|---|---|---|---|---|---|
| Antibody Function | Confirm the effect of the drug conjugation with the anti c-Met mAb and ADC on binding activity to target. | |||||
| Antibody Antigen Binding Assay | The binding affinity of SHR-A1403 to c-Met protein derived from human, cynomolgus monkey, and mouse was evaluated by the KD determined using Biacore assays and compared to that of naked SHR-A1403 mAb. | |||||
| Antibody Activity Information 2 | [1] | |||||
|
Dissociation Constant (Kd)
|
28.4
|
nM
|
||||
| Antibody Function | Confirm the effect of the drug conjugation with the anti c-Met mAb and ADC on binding activity to target. | |||||
| Antibody Antigen Binding Assay | The binding affinity of SHR-A1403 to c-Met protein derived from human, cynomolgus monkey, and mouse was evaluated by the KD determined using Biacore assays and compared to that of naked SHR-A1403 mAb. | |||||
Each Antibody-drug Conjugate Related to This Antibody
References