Antibody Information

General Information of This Antibody

Antibody ID	ANI0SDVFN
Antibody Name	h046-H4b/L7
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	G-protein coupled receptor 20 (GPR20)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

WO2018135501A1 ADC-4 [Investigative]

ADC Info

Discovered Using Patient-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≗ 60.00% (Day 89)	Positive GPR20 expression (GPR20+++/++)
Method Description	To establish gastrointestinal stromal tumor model, 5 x 10⁶ cells were implanted into the right flank of athymic nu/nu female donor mice. When tumors reached ~100 mm³ mice were randomly allocated to treatment groups. The dose of ADC was 10 mg/kg, i.v. at day55, day 75.
In Vivo Model	Gastrointestinal stromal tumor (GIST) PDX model (PDX: GIST020)

WO2018135501A1 ADC-3 [Investigative]

ADC Info

Discovered Using Patient-derived Xenograft Model

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≝ 81.30% (Day 71)	Positive GPR20 expression (GPR20+++/++)
Method Description	To establish gastrointestinal stromal tumor model, 5 x 10⁶ cells were implanted into the right flank of athymic nu/nu female donor mice. When tumors reached ~100 mm³ mice were randomly allocated to treatment groups. The dose of ADC was 3 mg/kg, i.v.*1.
In Vivo Model	Gastrointestinal stromal tumor (GIST) PDX model (PDX: GIST430/654)
Experiment 2 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≎ 88.60% (Day 46)	Positive GPR20 expression (GPR20+++/++)
Method Description	To establish gastrointestinal stromal tumor model, 5 x 10⁶ cells were implanted into the right flank of athymic nu/nu female donor mice. When tumors reached ~100 mm³ mice were randomly allocated to treatment groups. The dose of ADC was 1 mg/kg, i.v.*1.
In Vivo Model	Gastrointestinal stromal tumor (GIST) PDX model (PDX: GIST-T1/GPR20)

References

Ref 1	Anti-gpr20 antibody and anti-gpr20 antibody-drug conjugate; 2018-07-26.