Antibody Information

General Information of This Antibody

Antibody ID	ANI0KYBPE
Antibody Name	Anti-CDCP1 mAb 10D7
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	CUB domain-containing protein 1 (CDCP1)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

10D7-MMAE [Investigative]

ADC Info

Discovered Using Patient-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 100.00% (Day 24)	Positive CDCP1 expression (CDCP1 +++/++)
Method Description	Mice were randomized into groups of six and administered a single intravenous treatment of 10D7 MMAE (5 mg/kg), 10D7 (5 mg/kg), MMAE (0.17 mg/kg; equivalent to a four molar excess of the 10D7-MMAE dose) or vehicle.
In Vivo Model	Ovarian cancer PDX model (PDX: PH250)

References

Ref 1	Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer. Theranostics. 2020 Jan 12;10(5):2095-2114. doi: 10.7150/thno.30736. eCollection 2020.

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