Antigen Information

General Information of This Antigen (ID: TAR0QJKRF)
Antigen Name
CUB domain-containing protein 1 (CDCP1)
Gene Name
CDCP1
Gene ID
64866
Synonym
TRASK; UNQ2486; PRO5773; Membrane glycoprotein gp140;Subtractive immunization M plus HEp3-associated 135 kDa protein;Transmembrane and associated with src kinases;CD318
Sequence
MAGLNCGVSIALLGVLLLGAARLPRGAEAFEIALPRESNITVLIKLGTPTLLAKPCYIVI
SKRHITMLSIKSGERIVFTFSCQSPENHFVIEIQKNIDCMSGPCPFGEVQLQPSTSLLPT
LNRTFIWDVKAHKSIGLELQFSIPRLRQIGPGESCPDGVTHSISGRIDATVVRIGTFCSN
GTVSRIKMQEGVKMALHLPWFHPRNVSGFSIANRSSIKRLCIIESVFEGEGSATLMSANY
PEGFPEDELMTWQFVVPAHLRASVSFLNFNLSNCERKEERVEYYIPGSTTNPEVFKLEDK
QPGNMAGNFNLSLQGCDQDAQSPGILRLQFQVLVQHPQNESNKIYVVDLSNERAMSLTIE
PRPVKQSRKFVPGCFVCLESRTCSSNLTLTSGSKHKISFLCDDLTRLWMNVEKTISCTDH
RYCQRKSYSLQVPSDILHLPVELHDFSWKLLVPKDRLSLVLVPAQKLQQHTHEKPCNTSF
SYLVASAIPSQDLYFGSFCPGGSIKQIQVKQNISVTLRTFAPSFQQEASRQGLTVSFIPY
FKEEGVFTVTPDTKSKVYLRTPNWDRGLPSLTSVSWNISVPRDQVACLTFFKERSGVVCQ
TGRAFMIIQEQRTRAEEIFSLDEDVLPKPSFHHHSFWVNISNCSPTSGKQLDLLFSVTLT
PRTVDLTVILIAAVGGGVLLLSALGLIICCVKKKKKKTNKGPAVGIYNDNINTEMPRQPK
KFQKGRKDNDSHVYAVIEDTMVYGHLLQDSSGSFLQPEVDTYRPFQGTMGVCPPSPPTIC
SRAPTAKLATEEPPPRSPPESESEPYTFSHPNNGDVSSKDTDIPLLNTQEPMEPAE

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Function
May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.

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Uniprot Entry
CDCP1_HUMAN
HGNC ID
HGNC:24357
KEGG ID
hsa:64866
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CDCP1 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
RC278
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-CDCP1 mAb 10D7
 Antibody Info 
ADC Name Payload Target Linker ADC Info
10D7-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
Human Anti-CDCP1 h14A043-ATAC mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H14A043-ATAC [2]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
HY0001a
Monomethyl auristatin E
Microtubule (MT)
A cleavable linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
MHB046C
MH30010008
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD318-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
AU2023306656A1 ADC1 [4]
AU2023306656A1 ADC1 payload
Undisclosed
AU2023306656A1 ADC1 linker
 ADC Info 
AU2023306656A1 ADC2 [4]
AU2023306656A1 ADC2 payload
Undisclosed
Mc-Val-Ala
 ADC Info 
AU2023306656A1 ADC3 [4]
Exatecan
DNA topoisomerase 1 (TOP1)
AU2023306656A1 ADC3 linker
 ADC Info 
AU2023306656A1 ADC4 [4]
Exatecan
DNA topoisomerase 1 (TOP1)
AU2023306656A1 ADC3 linker
 ADC Info 
AU2023306656A1 ADC5 [4]
AU2023306656A1 ADC4 payload
Undisclosed
SG3932 Linker
 ADC Info 
AU2023306656A1 ADC7 [4]
AU2023306656A1 ADC5 payload
Undisclosed
AU2023306656A1 ADC5 linker
 ADC Info 
References
Ref 1 Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer. Theranostics. 2020 Jan 12;10(5):2095-2114. doi: 10.7150/thno.30736. eCollection 2020.
Ref 2 Antibody drug conjugate using a novel anti-CDCP1 antibody with low hematopoietic stem-cell binding and rapid internalization showed high efficacy for solid cancer. Cancer Res (2023) 83 (7_Supplement): 438.
Ref 3 TAVO605, a novel CD318 (CDCP1) ADC, for the treatment of solid cancers that are non-responding or resistant to Enhertu treatment
Ref 4 Antibody drug conjugates that bind CDCP1 and uses thereof