Antigen Information

General Information of This Antigen
Antigen ID
TAR0QJKRF
Antigen Name
CUB domain-containing protein 1 (CDCP1)
Gene Name
CDCP1
Synonym
TRASK; UNQ2486; PRO5773; Membrane glycoprotein gp140;Subtractive immunization M plus HEp3-associated 135 kDa protein;Transmembrane and associated with src kinases;CD_antigen=CD318
Sequence
MAGLNCGVSIALLGVLLLGAARLPRGAEAFEIALPRESNITVLIKLGTPTLLAKPCYIVI
SKRHITMLSIKSGERIVFTFSCQSPENHFVIEIQKNIDCMSGPCPFGEVQLQPSTSLLPT
LNRTFIWDVKAHKSIGLELQFSIPRLRQIGPGESCPDGVTHSISGRIDATVVRIGTFCSN
GTVSRIKMQEGVKMALHLPWFHPRNVSGFSIANRSSIKRLCIIESVFEGEGSATLMSANY
PEGFPEDELMTWQFVVPAHLRASVSFLNFNLSNCERKEERVEYYIPGSTTNPEVFKLEDK
QPGNMAGNFNLSLQGCDQDAQSPGILRLQFQVLVQHPQNESNKIYVVDLSNERAMSLTIE
PRPVKQSRKFVPGCFVCLESRTCSSNLTLTSGSKHKISFLCDDLTRLWMNVEKTISCTDH
RYCQRKSYSLQVPSDILHLPVELHDFSWKLLVPKDRLSLVLVPAQKLQQHTHEKPCNTSF
SYLVASAIPSQDLYFGSFCPGGSIKQIQVKQNISVTLRTFAPSFQQEASRQGLTVSFIPY
FKEEGVFTVTPDTKSKVYLRTPNWDRGLPSLTSVSWNISVPRDQVACLTFFKERSGVVCQ
TGRAFMIIQEQRTRAEEIFSLDEDVLPKPSFHHHSFWVNISNCSPTSGKQLDLLFSVTLT
PRTVDLTVILIAAVGGGVLLLSALGLIICCVKKKKKKTNKGPAVGIYNDNINTEMPRQPK
KFQKGRKDNDSHVYAVIEDTMVYGHLLQDSSGSFLQPEVDTYRPFQGTMGVCPPSPPTIC
SRAPTAKLATEEPPPRSPPESESEPYTFSHPNNGDVSSKDTDIPLLNTQEPMEPAE

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Function
May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.

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Uniprot Entry
CDCP1_HUMAN
HGNC ID
HGNC:24357
KEGG ID
hsa:64866
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CDCP1 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
rC278
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
A cleavable linker
Anti-CDCP1 mAb 10D7
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
10D7-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [1]
Human Anti-CDCP1 h14A043-ATAC mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
H14A043-ATAC
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Undisclosed
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
hY0001a
MMAE
Microtubule (MT)
A cleavable linker
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD318-MMAE
Monomethyl auristatin E
Undisclosed
Undisclosed
 [3]
 ADC Info 
AU2023306656A1 ADC1
AU2023306656A1 ADC1 payload
Undisclosed
AU2023306656A1 ADC1 linker
 [4]
 ADC Info 
AU2023306656A1 ADC2
AU2023306656A1 ADC2 payload
Undisclosed
Mc-Val-Ala
 [4]
 ADC Info 
AU2023306656A1 ADC3
Exatecan
Undisclosed
AU2023306656A1 ADC3 linker
 [4]
 ADC Info 
AU2023306656A1 ADC4
Exatecan
Undisclosed
AU2023306656A1 ADC3 linker
 [4]
 ADC Info 
AU2023306656A1 ADC5
AU2023306656A1 ADC4 payload
Undisclosed
SG3932 Linker
 [4]
 ADC Info 
AU2023306656A1 ADC7
AU2023306656A1 ADC5 payload
Undisclosed
AU2023306656A1 ADC5 linker
 [4]
References
Ref 1 Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer. Theranostics. 2020 Jan 12;10(5):2095-2114. doi: 10.7150/thno.30736. eCollection 2020.
Ref 2 Antibody drug conjugate using a novel anti-CDCP1 antibody with low hematopoietic stem-cell binding and rapid internalization showed high efficacy for solid cancer. Cancer Res (2023) 83 (7_Supplement): 438.
Ref 3 TAVO605, a novel CD318 (CDCP1) ADC, for the treatment of solid cancers that are non-responding or resistant to Enhertu treatment
Ref 4 Antibody drug conjugates that bind CDCP1 and uses thereof