Antibody Information

General Information of This Antibody

Antibody ID	ANI0KLJBJ
Antibody Name	Anti-MET lgG1
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	Hepatocyte growth factor receptor (MET)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

lgG1-Mc-Val-Cit-MMAE [Investigative]

ADC Info

Discovered Using Patient-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 42.13% (Day 21)	Positive MET expression (MET+++/++)
Method Description	Inoculate mice with gastric cancer cells at 3 million cells/mouse suspended in HBSS/matrigel, in the thoracic mammary fat pad at a volume of 0.2 ml. When tumors have reached a mean tumor volume of 100-250 mm³, they will be grouped. A single treatment will be administered intravenously (10 mg/kg) via the tail vein on Day 0.
In Vivo Model	Gastric cancer PDX model (PDX: GA0045)

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 0.00% (Day 21)	Positive MET expression (MET+++/++)
Method Description	Inoculate mice with MKN-45 cells at 3 million cells/mouse suspended in HBSS/matrigel, in the thoracic mammary fat pad at a volume of 0.2 ml. When tumors have reached a mean tumor volume of 100-250 mm³, they will be grouped. A single treatment will be administered intravenously (3 mg/kg) via the tail vein on Day 0.
In Vivo Model	MKN-45 CDX model
In Vitro Model	Gastric adenocarcinoma	MKN45 cells		CVCL_0434

References

Ref 1	Anti-c-met antibody-drug conjugate and applications thereof; 2022-03-10.