Antibody Information

General Information of This Antibody
Antibody ID
ANI0JXAWL
Antibody Name
Anti-ITGA2B scFv
Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized IgG1 scFv
Antigen Name
Integrin beta-3 (ITGB3)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
ScFvGPIIb/IIIa-MMAE [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.20 nM
High ITGA2B expression (ITGA2B+++/++)
Method Description
The MTT-based cytotoxicity assay in MDA-MB-231 cells that displayed a dose dependent cell killing of ADC treatment.
In Vitro Model Breast adenocarcinoma MDA-MB-231 cells CVCL_0062
References
Ref 1 Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases. Theranostics. 2019 Feb 7;9(4):1154-1169. doi: 10.7150/thno.29146. eCollection 2019.

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