Antigen Information

General Information of This Antigen
Antigen ID
TAR0YDDCE
Antigen Name
Alkaline phosphatase, germ cell type (ALPG); Alkaline phosphatase, placental type (ALPP)
Gene Name
ALPG; ALPP
Gene ID
251 , 250
Synonym1
ALP-1; Alkaline phosphatase Nagao isozyme; Alkaline phosphatase, placental-like; Germ cell alkaline phosphatase; Placental alkaline phosphatase-like (PLAP-like); ALPG; ALPPL; ALPPL2
Synonym2
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1 (PLAP-1); ALPP; PLAP
Sequence1
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

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Sequence2
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLII
FLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATA
YLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAG
TYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYP
DDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEI
HRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAI
ERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG
YVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFI
AHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP

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Family1
Alkaline phosphatase family
Family2
Alkaline phosphatase family
Function1
Alkaline phosphatase that can hydrolyze various phosphate compounds.

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Function2
Alkaline phosphatase that can hydrolyze various phosphate compounds.

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Uniprot Entry
PPBN_HUMAN , PPB1_HUMAN
HGNC ID
HGNC:441 , HGNC:439
KEGG ID
hsa:251 , hsa:250
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SGN-ALPV
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
References
Ref 1 Phase 1 study of SGN-ALPV, a novel, investigational vedotin antibodydrug conjugate directed to ALPP/ALPPL2 in advanced solid tumors (SGNALPV-001, trial in progress). Journal of Clinical Oncology 2022 40:16_suppl, TPS3159-TPS3159.