Antibody Information
General Information of This Antibody
| Antibody ID | ANI0IMZTX |
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| Antibody Name | SC16.103 |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized IgG1-kappa |
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| Antigen Name | Delta-like protein 3 (DLL3) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Varible Domain |
QVTLKESGPGILKPSQTLSLTCSFSGFSLSTSGMGIGWIRQPSGKGLEWLAHIWWDDDKY
YNPSLKSQLTISKDSSRNQVFLKITSVDTADTATYYCARRGTAYYFDYWGAGTTLTVSS Click to Show/Hide
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| Heavy Chain CDR 1 |
TSGMGIG
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| Heavy Chain CDR 2 |
HIWWDDDKYYNPSLKS
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| Heavy Chain CDR 3 |
RGTAYYFDY
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| Light Chain Varible Domain |
DIVLTQSPASLAVSLGQRATISCRASKSVSTSGYSYMHWYQQKPGQPPKLLIYLASNLES
GVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQHSRELPLTFGAGTKLELK Click to Show/Hide
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| Light Chain CDR 1 |
RASKSVSTSGYSYMH
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| Light Chain CDR 2 |
LASNLES
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| Light Chain CDR 3 |
QHSRELPLT
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
SC16.103-DL5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.13 nM
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Positive CD276 expression (CD276 +++/++) | ||
| Method Description |
The anti-tumor activity of these ADCs was tested in cytotoxicity assaysusing the HCC38 cell line. IC50 values were determined by quantitating viable cells using a CellTiter-Glo luminescent assay.
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| In Vitro Model | Breast ductal carcinoma | HCC38 cells | CVCL_1267 | ||
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