Antibody Information

General Information of This Antibody
Antibody ID
ANI0HPEEQ
Antibody Name
Anti-cleaved-AREG 1A3 antibody
Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Rabbit IgG
Antigen Name
Amphiregulin (AREG)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
GMF-1A3-MMAE [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 75.00% (Day 73) Low HER2 expression (HER2+)
Method Description
1A3-MMAE=5 mg/kg.
In Vivo Model MCF7 breast cancer xenograft model
In Vitro Model Invasive breast carcinoma MCF-7 cells CVCL_0031
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 100.00% (Day 21) Low HER2 expression (HER2+)
Method Description
1A3-MMAE=5 mg/kg.
In Vivo Model MCF7-F breast cancer xenograft model
In Vitro Model Invasive breast carcinoma MCF7-F (fulvestrant resistant) cells CVCL_0031
References
Ref 1 Anti-tumor efficacy of an MMAE-conjugated antibody targeting cell surface TACE/ADAM17-cleaved Amphiregulin in breast cancer. Antib Ther. 2021 Nov 10;4(4):252-261.

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