Antigen Information

General Information of This Antigen
Antigen ID
TAR0HXNLQ
Antigen Name
Amphiregulin (AREG)
Gene Name
AREG
Synonym
Colorectum cell-derived growth factor
Sequence
MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSG
SEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENT
SDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGER
CGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKK
LRQENGNVHAIA

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Family
Alpha-carbonic anhydrase family
Function
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of .get cells including astrocytes, Schwann cells and fibroblasts.

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Uniprot Entry
AREG_HUMAN
HGNC ID
HGNC:651
KEGG ID
hsa:374
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-cleaved-AREG 1A3 Anti-ody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
GMF-1A3-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
References
Ref 1 Anti-tumor efficacy of GMF-1A3, an MMAE-based antibody drug conjugate targeting cell surface cleaved Amphiregulin in breast cancer. Cancer Res (2023) 83 (7_Supplement): 562.