Antibody Information
General Information of This Antibody
Antibody ID | ANI0HDPWM |
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Antibody Name | Zaptuzumab |
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Synonyms |
AD5-10
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Antibody Type | Monoclonal antibody (mAb) |
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Antibody Subtype | Humanized IgG1-kappa |
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Antigen Name | Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) |
Antigen Info |
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Zapadcine-1 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 100.00% (Day 14) | Positive DR5 expression (DR5+++/++) | ||
Method Description |
Zapadcine-1 (9 mg/kg, Q3D3, every three days for 3 times) induces efficient tumor cell killing in cell line-derived models of Jurkat E6-1 cells with DR5 expression with high expression.
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In Vivo Model | Jurkat E6.1 CDX model | ||||
In Vitro Model | Leukemia | Jurkat E6.1 cells | CVCL_0367 |
References
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