General Information of This Antibody
Antibody ID
ANI0HDPWM
Antibody Name
Zaptuzumab
Synonyms
AD5-10
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Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized IgG1-kappa
Antigen Name
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
 Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Zapadcine-1 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 100.00% (Day 14) Positive DR5 expression (DR5+++/++)
Method Description
Zapadcine-1 (9 mg/kg, Q3D3, every three days for 3 times) induces efficient tumor cell killing in cell line-derived models of Jurkat E6-1 cells with DR5 expression with high expression.
In Vivo Model Jurkat E6.1 CDX model
In Vitro Model Leukemia Jurkat E6.1 cells CVCL_0367
References
Ref 1 A novel anti-DR5 antibody-drug conjugate possesses a high-potential therapeutic efficacy for leukemia and solid tumors. Theranostics. 2019 Jul 13;9(18):5412-5423. doi: 10.7150/thno.33598. eCollection 2019.

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