Antibody Information
General Information of This Antibody
| Antibody ID | ANI0GMJRR |
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| Antibody Name | c208F2 |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Chimeric IgG1-kappa |
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| Antigen Name | Insulin-like growth factor 1 receptor (IGF1R) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
c208F2-E-13 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 100.00% (Day 62) | Positive IGF1R expression (IGF1R+++/++) | ||
| Method Description |
Twenty days after MCF-7 cell implantation, when tumors reached an average size of 120-150 mm3, the animals were divided into groups of 5 mice according to tumor size and aspect. All compounds were injected intraperitoncally (i.p.). In this example, the anti-tumor activity of ADCs at about DAR 4 was evaluated after 2 injections of a 7 mg/kg dose at day 20 and day 27.
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| In Vivo Model | MCF-7 CDX model | ||||
| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
c208F2-G-13 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.10 nM
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Positive IGF1R expression (IGF1R+++/++) | ||
| Method Description |
MCF-7 cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
c208F2-F-13 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.10 nM
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Positive IGF1R expression (IGF1R+++/++) | ||
| Method Description |
MCF-7 cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
c208F2-F-63 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.10-1.00 nM
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Positive IGF1R expression (IGF1R+++/++) | ||
| Method Description |
MCF-7 cells were incubated with increasing concentrations of each ADCs at 37°C for 6 days in complete culture medium.
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
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