Antibody Information
General Information of This Antibody
| Antibody ID | ANI0DWGYQ |
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| Antibody Name | Anti CLL-1 THIOMAB antibody |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized IgG1-kappa |
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| Antigen Name | C-type lectin domain family 12 member A (CLEC12A) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Anti-CLL-1-ds-PBD [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 47.85% (Day 11) | Positive CLL-1 expression (CLL-1+++/++) | ||
| Method Description |
Three human AML cell lines, were used to establish subcutaneous xenograft models for evaluation of anti-CLL-1-ds-PBD efficacy. When mean tumor size reached the desired volume (200 mm3), animals were randomized into groups of n = 8, each with similar mean tumor size. Four hours later, animals in each group were given a single intravenous dose of vehicle or ADC (0.25 mg/kg) through the tail vein.
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| In Vivo Model | HL-60 CDX model | ||||
| In Vitro Model | Adult acute myeloid leukemia | HL-60 cells | CVCL_0002 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 57.73% (Day 14) | Moderate CLL-1 expression (CLL-1++) | ||
| Method Description |
Three human AML cell lines, were used to establish subcutaneous xenograft models for evaluation of anti-CLL-1-ds-PBD efficacy. When mean tumor size reached the desired volume (200 mm3), animals were randomized into groups of n = 8, each with similar mean tumor size. Four hours later, animals in each group were given a single intravenous dose of vehicle or ADC (0.75 mg/kg) through the tail vein.
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| In Vivo Model | THP1 CDX model | ||||
| In Vitro Model | Childhood acute monocytic leukemia | THP-1 cells | CVCL_0006 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 72.19% (Day 14) | Moderate CLL-1 expression (CLL-1++) | ||
| Method Description |
Three human AML cell lines, were used to establish subcutaneous xenograft models for evaluation of anti-CLL-1-ds-PBD efficacy. When mean tumor size reached the desired volume (200 mm3), animals were randomized into groups of n = 8, each with similar mean tumor size. Four hours later, animals in each group were given a single intravenous dose of vehicle or ADC (1.5 mg/kg) through the tail vein.
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| In Vivo Model | THP1 CDX model | ||||
| In Vitro Model | Childhood acute monocytic leukemia | THP-1 cells | CVCL_0006 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 80.28% (Day 11) | Positive CLL-1 expression (CLL-1+++/++) | ||
| Method Description |
Three human AML cell lines, were used to establish subcutaneous xenograft models for evaluation of anti-CLL-1-ds-PBD efficacy. When mean tumor size reached the desired volume (200 mm3), animals were randomized into groups of n = 8, each with similar mean tumor size. Four hours later, animals in each group were given a single intravenous dose of vehicle or ADC (0.5 mg/kg) through the tail vein.
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| In Vivo Model | HL-60 CDX model | ||||
| In Vitro Model | Adult acute myeloid leukemia | HL-60 cells | CVCL_0002 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 80.38% (Day 7) | Positive CLL-1 expression (CLL-1+++/++) | ||
| Method Description |
Three human AML cell lines, were used to establish subcutaneous xenograft models for evaluation of anti-CLL-1-ds-PBD efficacy. When mean tumor size reached the desired volume (200 mm3), animals were randomized into groups of n = 8, each with similar mean tumor size. Four hours later, animals in each group were given a single intravenous dose of vehicle or ADC (0.25 mg/kg) through the tail vein.
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| In Vivo Model | EOL-1 CDX model | ||||
| In Vitro Model | Chronic eosinophilic leukemia | EoL-1 cells | CVCL_0258 | ||
| Experiment 6 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 87.48% (Day 14) | Moderate CLL-1 expression (CLL-1++) | ||
| Method Description |
Three human AML cell lines, were used to establish subcutaneous xenograft models for evaluation of anti-CLL-1-ds-PBD efficacy. When mean tumor size reached the desired volume (200 mm3), animals were randomized into groups of n = 8, each with similar mean tumor size. Four hours later, animals in each group were given a single intravenous dose of vehicle or ADC (3 mg/kg) through the tail vein.
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| In Vivo Model | THP1 CDX model | ||||
| In Vitro Model | Childhood acute monocytic leukemia | THP-1 cells | CVCL_0006 | ||
| Experiment 7 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 90.88% (Day 7) | Positive CLL-1 expression (CLL-1+++/++) | ||
| Method Description |
Three human AML cell lines, were used to establish subcutaneous xenograft models for evaluation of anti-CLL-1-ds-PBD efficacy. When mean tumor size reached the desired volume (200 mm3), animals were randomized into groups of n = 8, each with similar mean tumor size. Four hours later, animals in each group were given a single intravenous dose of vehicle or ADC (0.5 mg/kg) through the tail vein.
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| In Vivo Model | EOL-1 CDX model | ||||
| In Vitro Model | Chronic eosinophilic leukemia | EoL-1 cells | CVCL_0258 | ||
| Experiment 8 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 96.23% (Day 7) | Positive CLL-1 expression (CLL-1+++/++) | ||
| Method Description |
Three human AML cell lines, were used to establish subcutaneous xenograft models for evaluation of anti-CLL-1-ds-PBD efficacy. When mean tumor size reached the desired volume (200 mm3), animals were randomized into groups of n = 8, each with similar mean tumor size. Four hours later, animals in each group were given a single intravenous dose of vehicle or ADC (1 mg/kg) through the tail vein.
Click to Show/Hide
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| In Vivo Model | EOL-1 CDX model | ||||
| In Vitro Model | Chronic eosinophilic leukemia | EoL-1 cells | CVCL_0258 | ||
| Experiment 9 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 97.90% (Day 11) | Positive CLL-1 expression (CLL-1+++/++) | ||
| Method Description |
Three human AML cell lines, were used to establish subcutaneous xenograft models for evaluation of anti-CLL-1-ds-PBD efficacy. When mean tumor size reached the desired volume (200 mm3), animals were randomized into groups of n = 8, each with similar mean tumor size. Four hours later, animals in each group were given a single intravenous dose of vehicle or ADC (1 mg/kg) through the tail vein.
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| In Vivo Model | HL-60 CDX model | ||||
| In Vitro Model | Adult acute myeloid leukemia | HL-60 cells | CVCL_0002 | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
8.00 ng/mL±2.00 ng/mL
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Positive CLL-1 expression (CLL-1+++/++) | ||
| Method Description |
Tumor cells were then blocked with excess amount of mouse IgG2a anti-ragweed antibody and treated with ADCs for 6 days at 37°C before cell viability was measured.
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| In Vitro Model | Chronic eosinophilic leukemia | EoL-1 cells | CVCL_0258 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
10.00 ng/mL±2.00 ng/mL
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Positive CLL-1 expression (CLL-1+++/++) | ||
| Method Description |
Tumor cells were then blocked with excess amount of mouse IgG2a anti-ragweed antibody and treated with ADCs for 6 days at 37°C before cell viability was measured.
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| In Vitro Model | Adult acute myeloid leukemia | HL-60 cells | CVCL_0002 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
81.00 ng/mL±9.00 ng/mL
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Moderate CLL-1 expression (CLL-1++) | ||
| Method Description |
Tumor cells were then blocked with excess amount of mouse IgG2a anti-ragweed antibody and treated with ADCs for 6 days at 37°C before cell viability was measured.
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| In Vitro Model | Childhood acute monocytic leukemia | THP-1 cells | CVCL_0006 | ||
References
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