Antigen Information

General Information of This Antigen

Antigen ID	TAR0FZYGA
Antigen Name	C-type lectin domain family 12 member A (CLEC12A)
Gene Name	CLEC12A
Gene ID	160364
Synonym	CLL1; DCAL2; MICL; C-type lectin-like molecule 1;Dendritic cell-associated lectin 2;Myeloid inhibitory C-type lectin-like receptor;CD_antigen=CD371
Sequence	MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAALFLTLLCLLLLIGLGVL ASMFHVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRE LYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMACAAQNASLLKINNKNALEFI KSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNMYCGYINRLYVQYYHC TYKKRMICEKMANPVQLGSTYFREA Click to Show/Hide
Function	Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of .get MAP kinases. Click to Show/Hide
Uniprot Entry	CL12A_HUMAN
HGNC ID	HGNC:31713
KEGG ID	hsa:160364

Each Antibody-drug Conjuate AND It's Component Related to This Antigen

Full List of The ADC Related to This Antigen

Anti-CLL-1 THIOMAB Anti-ody

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Anti-CLL-1-ds-PBD	SG2000	Human Deoxyribonucleic acid (hDNA)	Undisclosed	[1]

Fully humanized Anti-CLL1 mAb

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CLL1-ADC	D211	Human Deoxyribonucleic acid (hDNA)	Mal-PEG8-Val-Cit-PABC	[2]

MCLL0517A

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	DCLL9718S	PBD dimer	Human Deoxyribonucleic acid (hDNA)	Cleavable disulfide	[3]

References

Ref 1	An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia. Clin Cancer Res. 2019 Feb 15;25(4):1358-1368. doi: 10.1158/1078-0432.CCR-18-0333. Epub 2018 Jun 29.
Ref 2	CLT030, a leukemic stem cell-targeting CLL1 antibody-drug conjugate for treatment of acute myeloid leukemia. Blood Adv. 2018 Jul 24;2(14):1738-1749. doi: 10.1182/bloodadvances.2018020107.
Ref 3	A Phase I dose-escalation study of DCLL9718S, an antibody-drug conjugate targeting C-type lectin-like molecule-1 (CLL-1) in patients with acute myeloid leukemia. Am J Hematol. 2021 May 1;96(5):E175-E179. doi: 10.1002/ajh.26136. Epub 2021 Mar 11.