Antigen Information

General Information of This Antigen (ID: TAR0FZYGA)
Antigen Name
C-type lectin domain family 12 member A (CLEC12A)
Gene Name
CLEC12A
Gene ID
160364
Synonym
CLL1; DCAL2; MICL; C-type lectin-like molecule 1;Dendritic cell-associated lectin 2;Myeloid inhibitory C-type lectin-like receptor;CD371
Sequence
MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAALFLTLLCLLLLIGLGVL
ASMFHVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRE
LYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMACAAQNASLLKINNKNALEFI
KSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNMYCGYINRLYVQYYHC
TYKKRMICEKMANPVQLGSTYFREA

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Function
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of .get MAP kinases.

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Uniprot Entry
CL12A_HUMAN
HGNC ID
HGNC:31713
KEGG ID
hsa:160364
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
6E7.N54A LC K149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106714844B ADC-117 [1]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN106714844B ADC-118 [1]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN106714844B ADC-133 [1]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
Anti-CLL-1 THIOMAB Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CLL-1-ds-PBD [2]
SG2000
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
Fully humanized Anti-CLL1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CLL1-ADC [3]
D211
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Cit-PABC
 ADC Info 
MCLL0517A
 Antibody Info 
ADC Name Payload Target Linker ADC Info
IGAC-90 [4]
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 ADC Info 
References
Ref 1 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
Ref 2 An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia. Clin Cancer Res. 2019 Feb 15;25(4):1358-1368. doi: 10.1158/1078-0432.CCR-18-0333. Epub 2018 Jun 29.
Ref 3 CLT030, a leukemic stem cell-targeting CLL1 antibody-drug conjugate for treatment of acute myeloid leukemia. Blood Adv. 2018 Jul 24;2(14):1738-1749. doi: 10.1182/bloodadvances.2018020107.
Ref 4 Isoindolinone-glutarimide antibody conjugates, and uses thereof