Antibody Information

General Information of This Antibody
Antibody ID
ANI0CTLYJ
Antibody Name
Anti-ApoD antibody
Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized IgG
Antigen Name
Apolipoprotein D (APOD)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Anti-ApoD PBD [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 90.00% Positive APOD expression (APOD +++/++)
Method Description
Male Bl6 mice, at 9 weeks old (young) or 80 weeks old (old), were intravenously treated with the vehicle alone or with anti-ApoD antibody and PBD-conjugated IgG with a cleavable linker, each at a concentration of 0.3 mg/kg and 3 mg/kg in a single dose.
In Vivo Model NHDF CDX model
In Vitro Model Normal NHDF cells Homo sapiens
References
Ref 1 New Senolysis Approach via Antibody-Drug Conjugate Targeting of the Senescent Cell Marker Apolipoprotein D for Skin Rejuvenation. Int J Mol Sci. 2023 Mar 20;24(6):5857. doi: 10.3390/ijms24065857.

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