Antibody Information

General Information of This Antibody

Antibody ID	ANI0AOVUM
Antibody Name	Anti-KAAG1 mAb AB-3A4
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG
Antigen Name	Kidney-associated antigen 1 (KAAG1)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

AB-3A4-Val-Cit-MMAE [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 3 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	1.00 nM-2.00 nM	Positive KAAG1 expression (KAAG1 +++/++)
Method Description	In vitro cytotoxicity of ADCs against a panel of four multiple human cancer cell lines.
In Vitro Model	Ovarian serous cystadenocarcinoma	SK-OV-3 cells		CVCL_0532
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	1.00 nM-2.00 nM	Positive KAAG1 expression (KAAG1 +++/++)
Method Description	In vitro cytotoxicity of ADCs against a panel of four multiple human cancer cell lines.
In Vitro Model	Breast adenocarcinoma	MDA-MB-231 cells		CVCL_0062
Experiment 3 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	1.00 nM-2.00 nM	Positive KAAG1 expression (KAAG1 +++/++)
Method Description	In vitro cytotoxicity of ADCs against a panel of four multiple human cancer cell lines.
In Vitro Model	Prostate carcinoma	PC-3 cells		CVCL_0035

References

Ref 1	AB-3A4: A novel KAAG1-targeting antibody-drug conjugate is active in models of ovarian carcinoma, triple-negative breast cancer and castration-resistant prostate cancer. Cancer Res (2014) 74 (19_Supplement): 666.

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